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Lamin A/C, clone: 4A7, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 14-9688-80

Code : NEW

Additional Details : Weight : 0.09500kg

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Product Code. 15557606

  • £62.86 / 25µg


Estimated Shipment date
from Supplier 27-07-2018
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Description

Description

The monoclonal antibody 4A7 recognizes human, mouse, rabbit and hamster lamin A/C. Lamins are nuclear intermediate filament proteins that provide framework for the nuclear envelope, maintain cell morphology, and protect the nucleus from mechanical, thermal, and oxidative stresses. Lamins also play a role in nuclear assembly, chromatin organization, DNA replication, RNA transcription, cell signaling, and apoptosis. Lamin C is a splice variant of Lamin A and both are A-type lamins. Lamin A and C are crucial for skeletal and cardiac development and function. Defects in A-type lamins result in cardiomyopathy, muscular dystrophy, peripheral neuropathy, lipodystrophy, restrictive dermopathy, and progeroid disorders.This 4A7 antibody has been tested by immunocytochemistry of methanol-fixed and permeabilized cells and can be used at less than or equal to 10 μg/mL. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.Purity: Greater than 90%, as determined by SDS-PAGE.Aggregation: Less than 10%, as determined by HPLC.Filtration: 0.2μm post-manufacturing filtered.
Specifications

Specifications

Lamin A/C
Monoclonal
0.5mg/mL
PBS with 0.09% sodium azide; pH 7.2
P02545, P48678
RP11-54H19.1, CDCD1, CDDC, CMD1A, CMT2B1, EMD2, FPL, FPLD, HGPS, IDC, LDP1, LFP, LGMD1B, LMN1, LMNC, PRO1
Murine
Affinity chromatography
RUO
Antibody
Monoclonal
HamsterþHumanþMurineþRabbit
ELISAþImmunocytochemistryþImmunohistochemistry (Frozen)þMicroscopyþWestern Blot
4A7
Unconjugated
LMNA
Purified
Lmna
IgG1, kappa
25μg
Store at 2-8°C.
Primary
4000
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