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Lamin A/C Mouse, Alexa Fluor 488, Clone: 4A7, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 53-9688-80

Code : NEW

Additional Details : Weight : 0.09500kg

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Product Code. 15550277

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Disclaimers:

For Research Use Only.


Description

Description

The monoclonal antibody 4A7 recognizes human, mouse, rabbit and hamster lamin A/C. Lamins are nuclear intermediate filament proteins that provide framework for the nuclear envelope, maintain cell morphology, and protect the nucleus from mechanical, thermal, and oxidative stresses. Lamins also play a role in nuclear assembly, chromatin organization, DNA replication, RNA transcription, cell signaling, and apoptosis. Lamin C is a splice variant of Lamin A and both are A-type lamins. Lamin A and C are crucial for skeletal and cardiac development and function. Defects in A-type lamins result in cardiomyopathy, muscular dystrophy, peripheral neuropathy, lipodystrophy, restrictive dermopathy, and progeroid disorders.
Specifications

Specifications

Lamin A/C
4A7
Alexa Fluor 488
Conjugated
Murine
25μg
Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal
Microscopy
0.5mg/mL
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
LMNA, LMNC
IgG1
RUO
Primary
Rabbit