Lamin A/C Mouse, Alexa Fluor 488, Clone: 4A7, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 53-9688-82

Code: NEW

Additional Details:
Additional Details: Weight: 0.09500kg



Disclaimers: For Research Use Only.

Product Code. 15560277

Quantity Price
1 £ 186.31 / 100µg
Estimated Shipment date
from Supplier 03-05-2017
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Description and Specification

Specification

Regulatory Status RUO
Species Reactivity Hamster, Human, Mouse, Rabbit
Isotype IgG1
Monoclonal or Polyclonal Monoclonal
Applications Immunocytochemistry
Applications Immunohistochemistry (Frozen)
Applications Microscopy
Conjugate Alexa Fluor 488
Gene Alias LMNA, LMNC
Quantity 100μg
Clone 4A7
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Primary or Secondary Primary
Concentration 0.5mg/mL
Host Species Mouse
Antigen Lamin A/C
Format Conjugated

The monoclonal antibody 4A7 recognizes human, mouse, rabbit and hamster lamin A/C. Lamins are nuclear intermediate filament proteins that provide framework for the nuclear envelope, maintain cell morphology, and protect the nucleus from mechanical, thermal, and oxidative stresses. Lamins also play a role in nuclear assembly, chromatin organization, DNA replication, RNA transcription, cell signaling, and apoptosis. Lamin C is a splice variant of Lamin A and both are A-type lamins. Lamin A and C are crucial for skeletal and cardiac development and function. Defects in A-type lamins result in cardiomyopathy, muscular dystrophy, peripheral neuropathy, lipodystrophy, restrictive dermopathy, and progeroid disorders.