Tocris Bioscience™ L189
DNA ligase I, III and IV inhibitor
Brand: Tocris Bioscience™ 356150
Code : Z1
Additional Details : Weight : 0.01000kg
DescriptionDNA ligase I, III and IV inhibitor (IC 50 values are 5, 9 and 5 μM respectively) that blocks DNA binding (K i = 5 μM for DNA ligase I). Preferentially inhibits step 2 of the ligation reaction, and inhibits base excision repair (BER) and non-homologous end joining (NHEJ). Specifically sensitizes cancer cells to DNA damage and increases the cytotoxicity of DNA-damaging agents.
For Research Use Only