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L-838,417, Tocris Bioscience™

GABAA partial agonist; displays subtype selectivity

Brand:  Tocris (Bio-Techne) 325010

Code : Z1

Additional Details : Weight : 0.01000kg

Quantity 10mg

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Product Code. 13442654

  • £145.80 / 10mg

Estimated Shipment
27-06-2019

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Description

Description

Subtype-selective GABAA receptor partial agonist. Selectively binds to α1, α2, α3 and α5 subunits (Ki values are 0.79, 0.67, 0.67 and 2.25 nM respectively) but displays no efficacy at α1 (α1-sparing). Exhibits non-sedative anxiolytic, antinociceptive and anti-inflammatory activity in vivo.
Specifications

Chemical Identifiers

286456-42-6
399.406
unii-8czo0970g3, 3-2,5-difluorophenyl-7-1,1-dimethylethyl-6-1-methyl-1h-1,2,4-triazol-5-yl methoxy-1,2,4-triazolo 4,3-b pyridazine, 7-tert-butyl-3-2,5-difluorophenyl-6-1-methyl-1h-1,2,4-triazol-5-yl methoxy-1,2,4 triazolo 4,3-b pyridazine, 5-7-tert-butyl-3-2,5-difluorophenyl-1,2,4 triazolo 4,3-b pyridazin-6-yl oxy methyl-1-methyl-1,2,4-triazole, 1,2,4-triazolo 4,3-b pyridazine, 3-2,5-difluorophenyl-7-1,1-dimethylethyl-6-1-methyl-1h-1,2,4-triazol-5-yl methoxy, l hplc, 1,2,4-triazolo 4,3-b pyridazine,3-2,5-difluorophenyl-7-1,1-dimethylethyl-6-1-methyl-1h-1,2,4-triazol-5-yl methoxy, 3-2,5-difluorophenyl-7-1,1-dimethylethyl-6-2-methyl-2h-1,2,4-triazol-3-ylmethoxy-1,2,4-triazolo 4,3-b pyridazine, 3-2,5-difluorophenyl-7-1,1-dimethylethyl-6-2-methyl-2h-1,2,4-triazol-3-ylmethoxy-1,2,4-triazolo 4,3-b pyridazine, 3-2,5-difluorophenyl-7-1,1-dimethylethyl-6-1-methyl-1h-1,2,4,-triazol-5-yl methoxy-1,2,4-triazolo 4,3-b pyridazine
7-tert-butyl-3-(2,5-difluorophenyl)-6-[(2-methyl-1,2,4-triazol-3-yl)methoxy]-[1,2,4]triazolo[4,3-b]pyridazine
C19H19F2N7O
BQDUNOMMYOKHEP-UHFFFAOYSA-N
9908880
CC(C)(C)C1=CC2=NN=C(N2N=C1OCC3=NC=NN3C)C4=C(C=CC(=C4)F)F

Specifications

L-838, 417
286456-42-6
unii-8czo0970g3, 3-2,5-difluorophenyl-7-1,1-dimethylethyl-6-1-methyl-1h-1,2,4-triazol-5-yl methoxy-1,2,4-triazolo 4,3-b pyridazine, 7-tert-butyl-3-2,5-difluorophenyl-6-1-methyl-1h-1,2,4-triazol-5-yl methoxy-1,2,4 triazolo 4,3-b pyridazine, 5-7-tert-butyl-3-2,5-difluorophenyl-1,2,4 triazolo 4,3-b pyridazin-6-yl oxy methyl-1-methyl-1,2,4-triazole, 1,2,4-triazolo 4,3-b pyridazine, 3-2,5-difluorophenyl-7-1,1-dimethylethyl-6-1-methyl-1h-1,2,4-triazol-5-yl methoxy, l hplc, 1,2,4-triazolo 4,3-b pyridazine,3-2,5-difluorophenyl-7-1,1-dimethylethyl-6-1-methyl-1h-1,2,4-triazol-5-yl methoxy, 3-2,5-difluorophenyl-7-1,1-dimethylethyl-6-2-methyl-2h-1,2,4-triazol-3-ylmethoxy-1,2,4-triazolo 4,3-b pyridazine, 3-2,5-difluorophenyl-7-1,1-dimethylethyl-6-2-methyl-2h-1,2,4-triazol-3-ylmethoxy-1,2,4-triazolo 4,3-b pyridazine, 3-2,5-difluorophenyl-7-1,1-dimethylethyl-6-1-methyl-1h-1,2,4,-triazol-5-yl methoxy-1,2,4-triazolo 4,3-b pyridazine
CC(C)(C)C1=CC2=NN=C(N2N=C1OCC3=NC=NN3C)C4=C(C=CC(=C4)F)F
399.406
399.4
10mg
C19H19F2N7O
BQDUNOMMYOKHEP-UHFFFAOYSA-N
7-tert-butyl-3-(2,5-difluorophenyl)-6-[(2-methyl-1,2,4-triazol-3-yl)methoxy]-[1,2,4]triazolo[4,3-b]pyridazine
9908880
>98%
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