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L 006235, Tocris Bioscience™

Potent cathepsin K inhibitor

Brand:  Tocris (Bio-Techne) 306650

Code : Z1

Additional Details : Weight : 0.01000kg

Quantity 50mg

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Product Code. 13452334

  • £958.44 / 50mg

Estimated Shipment date
from Supplier 27-03-2020

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Description

Description

Potent, reversible cathepsin K inhibitor (IC50 = 0.25 nM) that displays > 4000-fold selectivity over cathepsins B, L and S. Displays reduced selectivity in cell-based assays possibly due to lysosomal accumulation. Reduces collagen breakdown and promotes bone deposition in vivo. Orally active and has intrinsic fluorescence.
Specifications

Chemical Identifiers

294623-49-7
466.604
n-1-cyanomethyl carbamoyl cyclohexyl-4-2-4-methylpiperazin-1-yl thiazol-4-yl benzamide, n-1-cyanomethyl amino carbonyl cyclohexyl-4-2-4-methyl-1-piperazinyl-4-thiazolyl benzamide, d0z0pr, basic piperazine-containing compound, 1, n-1-cyanomethyl carbamoyl cyclohexyl-4-2-4-methylpiperazin-1-yl-1,3-thiazol-4-yl benzamide
N-[1-(cyanomethylcarbamoyl)cyclohexyl]-4-[2-(4-methylpiperazin-1-yl)-1,3-thiazol-4-yl]benzamide
C24H30N6O2S
FIVYCSWOCXEWSE-UHFFFAOYSA-N
9912381
CN1CCN(CC1)C2=NC(=CS2)C3=CC=C(C=C3)C(=O)NC4(CCCCC4)C(=O)NCC#N

Specifications

50mg
294623-49-7
n-1-cyanomethyl carbamoyl cyclohexyl-4-2-4-methylpiperazin-1-yl thiazol-4-yl benzamide, n-1-cyanomethyl amino carbonyl cyclohexyl-4-2-4-methyl-1-piperazinyl-4-thiazolyl benzamide, d0z0pr, basic piperazine-containing compound, 1, n-1-cyanomethyl carbamoyl cyclohexyl-4-2-4-methylpiperazin-1-yl-1,3-thiazol-4-yl benzamide
CN1CCN(CC1)C2=NC(=CS2)C3=CC=C(C=C3)C(=O)NC4(CCCCC4)C(=O)NCC#N
466.604
466.6
L 006235
C24H30N6O2S
FIVYCSWOCXEWSE-UHFFFAOYSA-N
N-[1-(cyanomethylcarbamoyl)cyclohexyl]-4-[2-(4-methylpiperazin-1-yl)-1,3-thiazol-4-yl]benzamide
9912381
>98%
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