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Ko 143, Tocris Bioscience™

Potent and selective BCRP inhibitor

Brand:  RD Systems (Bio-Techne) 32411

Code : Z1

Additional Details : Weight : 0.01000kg

Quantity 1mg

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Product Code. 13442634

  • £119.07 / 1mg

Estimated Shipment date
from Supplier 21-11-2019

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Description

Description

Potent and selective breast cancer resistance protein multidrug transporter (BCRP) inhibitor (EC90 = 26 nM). Displays > 200-fold selectivity over P-gp and MRP-1 transporters. Increases intracellular drug accumulation and reverses BCRP-mediated multidrug resistance. Inhibits ABCB1 and ABCC1 at higher concentrations. Rapidly metabolized in rat plasma.
Specifications

Chemical Identifiers

461054-93-3
469.582
tert-butyl 3-3s,6s,12as-6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino 1',2':1,6 pyrido 3,4-b indol-3-yl propanoate, ko143 hydrate, 3s,6s,12as-1,2,3,4,6,7,12,12a-octahydro-9-methoxy-6-2-methylpropyl-1,4-dioxopyrazino 1',2':1,6 pyrido 3,4-b indole-3-propanoic acid 1,1-dimethylethyl ester, 3s,6s,12as-,2,3,4,6,7,12,12a-octahydro-9-methoxy-6-2-methylpropyl-1,4-dioxopyrazino 1',2':1,6 pyrido 3,4-b indole-3-propanoic acid 1,1-dimethylethyl ester, 3s,6s,12as-1,2,3,4,6,7,12,12a-octahydro-9-methoxy-6-2-methylpropyl-1,4-dioxopyrazino 1',2':1,6 pyrido 3,4-b indole-3-propanoic acid 1,1-dimethylethyl ester hydrate, 3s,6s,12as-1,2,3,4,6,7,12,12a-octahydro-9-methoxy-6-2-methylpropyl 1,4-dioxopyrazino 1',2':1,6 pyrido 3,4-b indole-3-propanoic acid 1,1-dimethylethyl ester, 3s,6s,12as-1,2,3,4,6,7,12,12a-octahydro-9-methoxy-6-2-methylpropyl-1,4-dioxopyrazino 1,2:1,6 pyrido 3,4-b indole-3-propanoic acid 1,1-dimethylethyl ester, 1,1-dimethylethyl 3s,6s,12as-1,2,3,4,6,7,12,12a-octahydro-9-methoxy-6-2-methylpropyl-1,4-dioxopyrazino 1',2':1,6 pyrido 3,4-b indole-3-propanoate, 3-3s,6s-6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydro-pyrazino 1,2:1,6 pyrido 3,4-b indol-3-yl-propionic acid tert-butyl ester, 3-3s,6s,12as-6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydro-pyrazino 1,2:1,6 pyrido 3,4-b indol-3-yl-propionic acid tert-butyl ester
CC(C)CC1C2=C(CC3N1C(=O)C(NC3=O)CCC(=O)OC(C)(C)C)C4=C(N2)C=C(C=C4)OC
C26H35N3O5
NXNRAECHCJZNRF-JBACZVJFSA-N
10322450

Specifications

1mg
461054-93-3
tert-butyl 3-3s,6s,12as-6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino 1',2':1,6 pyrido 3,4-b indol-3-yl propanoate, ko143 hydrate, 3s,6s,12as-1,2,3,4,6,7,12,12a-octahydro-9-methoxy-6-2-methylpropyl-1,4-dioxopyrazino 1',2':1,6 pyrido 3,4-b indole-3-propanoic acid 1,1-dimethylethyl ester, 3s,6s,12as-,2,3,4,6,7,12,12a-octahydro-9-methoxy-6-2-methylpropyl-1,4-dioxopyrazino 1',2':1,6 pyrido 3,4-b indole-3-propanoic acid 1,1-dimethylethyl ester, 3s,6s,12as-1,2,3,4,6,7,12,12a-octahydro-9-methoxy-6-2-methylpropyl-1,4-dioxopyrazino 1',2':1,6 pyrido 3,4-b indole-3-propanoic acid 1,1-dimethylethyl ester hydrate, 3s,6s,12as-1,2,3,4,6,7,12,12a-octahydro-9-methoxy-6-2-methylpropyl 1,4-dioxopyrazino 1',2':1,6 pyrido 3,4-b indole-3-propanoic acid 1,1-dimethylethyl ester, 3s,6s,12as-1,2,3,4,6,7,12,12a-octahydro-9-methoxy-6-2-methylpropyl-1,4-dioxopyrazino 1,2:1,6 pyrido 3,4-b indole-3-propanoic acid 1,1-dimethylethyl ester, 1,1-dimethylethyl 3s,6s,12as-1,2,3,4,6,7,12,12a-octahydro-9-methoxy-6-2-methylpropyl-1,4-dioxopyrazino 1',2':1,6 pyrido 3,4-b indole-3-propanoate, 3-3s,6s-6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydro-pyrazino 1,2:1,6 pyrido 3,4-b indol-3-yl-propionic acid tert-butyl ester, 3-3s,6s,12as-6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydro-pyrazino 1,2:1,6 pyrido 3,4-b indol-3-yl-propionic acid tert-butyl ester
CC(C)CC1C2=C(CC3N1C(=O)C(NC3=O)CCC(=O)OC(C)(C)C)C4=C(N2)C=C(C=C4)OC
10322450
>99%
Ko 143
C26H35N3O5
NXNRAECHCJZNRF-JBACZVJFSA-N
469.582
469.57
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