KLRG1 Golden Syrian Hamster anti-Mouse, eFluor 450, Clone: 2F1, eBioscience™

Golden Syrian Hamster Monoclonal Antibody

Brand:  Affymetrix eBioscience 48-5893-82

Product Code. 15341800

Disclaimers:

For Research Use Only.

Description

This 2F1 monoclonal antibody reacts with the mouse Killer cell Lectin-like Receptor G1 (KLRG1), also known as Mast cell Function-associated Antigen (MAFA). KLRG1 is a homodimer of glycosylated 30-38kDa subunits and contains a cytoplasmic motif similar to the immunoreceptor tyrosine-based inhibitory motif (ITIM). Rat MAFA was identified as an antigen specific to rat mast cells; however, the expression of mouse KLRG1/MAFA using 2F1 has not been detected on the surface of mouse mast cell lines, bone marrow-derived mast cells, or peritoneal mast cells. This antigen is expressed on approximately one-third of mouse NK cells and a subset of T cells. MHC class I molecules regulate KLRG1 via interactions with class I-specific inhibitory Ly49 molecules and SHP-1 signaling. Although KLRG1 and Ly49 are both lectin-like inhibitory receptors that are regulated by class I MHC expression, the effects of this on cell surface expression of these molecules are opposing, and the underlying regulatory mechanisms distinct.

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Specifications

• Antigen: KLRG1
• Clone: 2F1
• Conjugate: eFluor 450
• Formulation: aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
• Host Species: Golden Syrian Hamster
• Quantity: 100μg
• Storage Requirements: Store at 2-8°C. Do not freeze. Light-sensitive material.
• Monoclonal or Polyclonal: Monoclonal

• Applications: Flow Cytometry
• Concentration: 0.2mg/mL
• Format: Conjugated
• Gene Alias: MAFA
• Isotype: IgG
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Target Species: Murine