KLRG1 Golden Syrian Hamster anti-Mouse, Clone: 2F1, Functional Grade, eBioscience™

Golden Syrian Hamster Monoclonal Antibody, Functional Grade

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 16-5893-85

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.01000kg



Disclaimers: For Research Use Only.

Product Code. 15228687

Quantity Price
1 £ 195.05 / 500µg
Estimated Shipment date
from Supplier 03-05-2017
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Description and Specification

Specification

Host Species Golden Syrian Hamster
Format Purified
Quantity 500μg
Applications Flow Cytometry
Applications Functional Assay
Antigen KLRG1
Regulatory Status RUO
Concentration 1mg/mL
Conjugate Unlabeled
Primary or Secondary Primary
Gene Alias MAFA
Isotype IgG
Clone 2F1
Formulation aqueous buffer, no sodium azide
Storage Requirements Store at 2-8°C.
Species Reactivity Mouse
Monoclonal or Polyclonal Monoclonal

This 2F1 monoclonal antibody reacts with the mouse Killer cell Lectin-like Receptor G1 (KLRG1), also known as Mast cell Function-associated Antigen (MAFA). KLRG1 is a homodimer of glycosylated 30-38kDa subunits and contains a cytoplasmic motif similar to the immunoreceptor tyrosine-based inhibitory motif (ITIM). Rat MAFA was identified as an antigen specific to rat mast cells; however, the expression of mouse KLRG1/MAFA using 2F1 has not been detected on the surface of mouse mast cell lines, bone marrow-derived mast cells, or peritoneal mast cells. This antigen is expressed on approximately one-third of mouse NK cells and a subset of T cells. MHC class I molecules regulate KLRG1 via interactions with class I-specific inhibitory Ly49 molecules and SHP-1 signaling. Although KLRG1 and Ly49 are both lectin-like inhibitory receptors that are regulated by class I MHC expression, the effects of this on cell surface expression of these molecules are opposing, and the underlying regulatory mechanisms distinct.