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KLRG1 Golden Syrian Hamster anti-Mouse, Clone: 2F1, Functional Grade, eBioscience™

Golden Syrian Hamster Monoclonal Antibody, Functional Grade

Brand:  Affymetrix eBioscience 16-5893-85

Code : Z2

Additional Details : Weight : 0.01000kg

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Product Code. 15228687

  • £195.05 / 500µg


Estimated Shipment
30-11-2017
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Disclaimers:

For Research Use Only.


Description

Description

This 2F1 monoclonal antibody reacts with the mouse Killer cell Lectin-like Receptor G1 (KLRG1), also known as Mast cell Function-associated Antigen (MAFA). KLRG1 is a homodimer of glycosylated 30-38kDa subunits and contains a cytoplasmic motif similar to the immunoreceptor tyrosine-based inhibitory motif (ITIM). Rat MAFA was identified as an antigen specific to rat mast cells; however, the expression of mouse KLRG1/MAFA using 2F1 has not been detected on the surface of mouse mast cell lines, bone marrow-derived mast cells, or peritoneal mast cells. This antigen is expressed on approximately one-third of mouse NK cells and a subset of T cells. MHC class I molecules regulate KLRG1 via interactions with class I-specific inhibitory Ly49 molecules and SHP-1 signaling. Although KLRG1 and Ly49 are both lectin-like inhibitory receptors that are regulated by class I MHC expression, the effects of this on cell surface expression of these molecules are opposing, and the underlying regulatory mechanisms distinct.
Specifications

Specifications

KLRG1
2F1
Unconjugated
Purified
Golden Syrian Hamster
500μg
Store at 2-8°C.
Monoclonal
Functional Assay
1mg/mL
aqueous buffer, no sodium azide
MAFA
IgG
RUO
Primary
Murine