KLRG1 Golden Syrian Hamster anti-Mouse, Clone: 2F1, Functional Grade, eBioscience™

Golden Syrian Hamster Monoclonal Antibody, Functional Grade

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 16-5893-82

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.01000kg



Disclaimers: For Research Use Only.

Product Code. 15218687

Quantity Price
1 £ 78.88 / 100µg
Estimated Shipment date
from Supplier 08-05-2017
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Description and Specification

Specification

Format Purified
Species Reactivity Mouse
Storage Requirements Store at 2-8°C.
Formulation aqueous buffer, no sodium azide
Antigen KLRG1
Regulatory Status RUO
Isotype IgG
Applications Flow Cytometry
Applications Functional Assay
Monoclonal or Polyclonal Monoclonal
Gene Alias MAFA
Host Species Golden Syrian Hamster
Concentration 1mg/mL
Quantity 100μg
Conjugate Unlabeled
Primary or Secondary Primary
Clone 2F1

This 2F1 monoclonal antibody reacts with the mouse Killer cell Lectin-like Receptor G1 (KLRG1), also known as Mast cell Function-associated Antigen (MAFA). KLRG1 is a homodimer of glycosylated 30-38kDa subunits and contains a cytoplasmic motif similar to the immunoreceptor tyrosine-based inhibitory motif (ITIM). Rat MAFA was identified as an antigen specific to rat mast cells; however, the expression of mouse KLRG1/MAFA using 2F1 has not been detected on the surface of mouse mast cell lines, bone marrow-derived mast cells, or peritoneal mast cells. This antigen is expressed on approximately one-third of mouse NK cells and a subset of T cells. MHC class I molecules regulate KLRG1 via interactions with class I-specific inhibitory Ly49 molecules and SHP-1 signaling. Although KLRG1 and Ly49 are both lectin-like inhibitory receptors that are regulated by class I MHC expression, the effects of this on cell surface expression of these molecules are opposing, and the underlying regulatory mechanisms distinct.