Tocris Bioscience™ Ki 8751

Potent, selective VEGFR-2 inhibitor

Description

Potent, selective inhibitor of VEGFR-2 tyrosine kinase (IC50 = 0.9 nM). Displays some inhibitory activity towards c-Kit, PDGFRα and FGFR-2 (IC50 values range from 40 to 170 nM) but is highly selective over other receptor tyrosine kinases (IC50 > 10000 nM for FGFR-2, EGFR and HGFR). Inhibits VEGF-stimulated proliferation of human umbilical vein endothelial cells (HUVEC) and inhibits tumor growth in vivo; antiangiogenic.

Specifications

• Chemical Name or Material: N-(2,4-Difluorophenyl)-N'-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]-2-fluorophenyl]urea
• Assay Percent Range: >97%
• Molecular Formula: C₂₄H₁₈F₃N₃O₄

• CAS: 228559-41-9
• Solubility: Soluble to 100mM in DMSO
• Formula Weight: Observed MW: 469.41

For Research Use Only