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Tocris Bioscience™ Ki 8751

Potent, selective VEGFR-2 inhibitor

Brand:  Tocris Bioscience™ 254210

Code : Z1

Additional Details : Weight : 0.01000kg

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Product Code. 13441434

  • £210.21 / 10mg

Estimated Shipment date
from Supplier 20-11-2019

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Description

Description

Potent, selective inhibitor of VEGFR-2 tyrosine kinase (IC50 = 0.9 nM). Displays some inhibitory activity towards c-Kit, PDGFRα and FGFR-2 (IC50 values range from 40 to 170 nM) but is highly selective over other receptor tyrosine kinases (IC50 > 10000 nM for FGFR-2, EGFR and HGFR). Inhibits VEGF-stimulated proliferation of human umbilical vein endothelial cells (HUVEC) and inhibits tumor growth in vivo; antiangiogenic.
Specifications

Specifications

N-(2,4-Difluorophenyl)-N'-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]-2-fluorophenyl]urea
>97%
Observed MW: 469.41
Soluble to 100mM in DMSO
228559-41-9
C24H18F3N3O4
10mg
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