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JW 55, Tocris Bioscience™

Tankyrase inhibitor

Brand:  RD Systems (Bio-Techne) 4514/10

Code : Z1

Additional Details : Weight : 0.00010kg

Quantity 10mg

 View more versions of this product

Product Code. 13434864

  • £158.76 / 10mg

Estimated Shipment date
from Supplier 19-11-2019

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Description

Description

Inhibitor of the PARP domain of tankyrase 1 and 2 (TNKS1/2). Activity results in stabilization of Axin2 and increased degradation of β-catenin; inhibits the β-catenin signaling pathway. Also shown to decrease canonical Wnt signaling in SW480 and HCT-15 colon carcinoma cell lines; reduces cell cycle progression and proliferation in SW480 cells in vitro.
Specifications

Chemical Identifiers

664993-53-7
434.492
n-4-4-4-methoxyphenyl oxan-4-yl methylcarbamoyl phenyl furan-2-carboxamide, n-4-4-4-methoxyphenyl tetrahydro-2h-pyran-4-yl methyl carbamoyl phenyl furan-2-carboxamide, qcr-64, n-4-4-4-methoxyphenyl oxan-4-yl methyl carbamoyl phenyl furan-2-carboxamide, n-4-4-4-methoxyphenyl tetrahydro-2h-pyran-4-ylmethylcarbamoyl phenyl furan-2-carboxamide, n-4-4-4-methoxyphenyl tetrahydro-2h-pyran-4-yl methylcarbamoyl phenyl furan-2-carboxamide, n-4-4-4-methoxyphenyl tetrahydro-2h-pyran-4-yl methyl amino carbonyl phenyl-2-furamide, n-4-tetrahydro-4-4-methoxyphenyl-2h-pyran-4-yl methyl amino carbonyl phenyl-2-furancarboxamide
N-[4-[[4-(4-methoxyphenyl)oxan-4-yl]methylcarbamoyl]phenyl]furan-2-carboxamide
C25H26N2O5
ZJZWZIXSGNFWQQ-UHFFFAOYSA-N
2946601
COC1=CC=C(C=C1)C2(CCOCC2)CNC(=O)C3=CC=C(C=C3)NC(=O)C4=CC=CO4

Specifications

10mg
664993-53-7
n-4-4-4-methoxyphenyl oxan-4-yl methylcarbamoyl phenyl furan-2-carboxamide, n-4-4-4-methoxyphenyl tetrahydro-2h-pyran-4-yl methyl carbamoyl phenyl furan-2-carboxamide, qcr-64, n-4-4-4-methoxyphenyl oxan-4-yl methyl carbamoyl phenyl furan-2-carboxamide, n-4-4-4-methoxyphenyl tetrahydro-2h-pyran-4-ylmethylcarbamoyl phenyl furan-2-carboxamide, n-4-4-4-methoxyphenyl tetrahydro-2h-pyran-4-yl methylcarbamoyl phenyl furan-2-carboxamide, n-4-4-4-methoxyphenyl tetrahydro-2h-pyran-4-yl methyl amino carbonyl phenyl-2-furamide, n-4-tetrahydro-4-4-methoxyphenyl-2h-pyran-4-yl methyl amino carbonyl phenyl-2-furancarboxamide
COC1=CC=C(C=C1)C2(CCOCC2)CNC(=O)C3=CC=C(C=C3)NC(=O)C4=CC=CO4
434.492
434.48
JW 55
C25H26N2O5
ZJZWZIXSGNFWQQ-UHFFFAOYSA-N
N-[4-[[4-(4-methoxyphenyl)oxan-4-yl]methylcarbamoyl]phenyl]furan-2-carboxamide
2946601
>98%
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