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JK 184, Tocris Bioscience™

Alcohol dehydrogenase 7 inhibitor; inhibits downstream Hh signaling pathway

Brand:  Tocris (Bio-Techne) 334110

Code : Z1

Additional Details : Weight : 0.01000kg

Quantity 10mg

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Product Code. 13442844

  • £169.05 / 10mg

Estimated Shipment date
from Supplier 28-10-2019

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Description

Description

Potent downstream hedgehog (Hh) signaling inhibitor that prevents Gli-dependent transcriptional activity (IC50 = 30 nM). Exhibits antiproliferative activity in a range of cancer cell lines (GI50 = 3 - 21 nM) and in human xenografts in vivo. Inhibits alcohol dehydrogenase 7 (Adh7) (IC50 = 210 nM) and acts as a microtubule depolymerizing agent in vitro.
Specifications

Chemical Identifiers

315703-52-7
350.44
n-4-ethoxyphenyl-4-2-methylimidazo 1,2-a pyridin-3-yl thiazol-2-amine, hh signaling antagonist vii, jk184, n-4-ethoxyphenyl-4-2-methylimidazo 1,2-a pyridin-3-yl-2-thiazolamine, n-4-ethoxyphenyl-4-2-methylimidazo 1,2-a pyridin-3-yl-1,3-thiazol-2-amine, shh antagonist, hh signaling antagonist vii, 3-2-4-ethoxyphenyl amino thiazole-4-yl-2-methylimidazo 1,2-a pyridine, 2-thiazolamine, n-4-ethoxyphenyl-4-2-methylimidazo 1,2-a pyridin-3-yl, n-4-ethoxyphenyl-4-2-methylimidazo-1,2-a pyridin-3-yl thiazol-2-amine
N-(4-ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)-1,3-thiazol-2-amine
C19H18N4OS
ROYXIPOUVGDTAO-UHFFFAOYSA-N
1069686
CCOC1=CC=C(C=C1)NC2=NC(=CS2)C3=C(N=C4N3C=CC=C4)C

Specifications

10mg
315703-52-7
n-4-ethoxyphenyl-4-2-methylimidazo 1,2-a pyridin-3-yl thiazol-2-amine, hh signaling antagonist vii, jk184, n-4-ethoxyphenyl-4-2-methylimidazo 1,2-a pyridin-3-yl-2-thiazolamine, n-4-ethoxyphenyl-4-2-methylimidazo 1,2-a pyridin-3-yl-1,3-thiazol-2-amine, shh antagonist, hh signaling antagonist vii, 3-2-4-ethoxyphenyl amino thiazole-4-yl-2-methylimidazo 1,2-a pyridine, 2-thiazolamine, n-4-ethoxyphenyl-4-2-methylimidazo 1,2-a pyridin-3-yl, n-4-ethoxyphenyl-4-2-methylimidazo-1,2-a pyridin-3-yl thiazol-2-amine
CCOC1=CC=C(C=C1)NC2=NC(=CS2)C3=C(N=C4N3C=CC=C4)C
350.44
350.44
JK 184
C19H18N4OS
ROYXIPOUVGDTAO-UHFFFAOYSA-N
N-(4-ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)-1,3-thiazol-2-amine
1069686
>99%
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