Jagged 2 Armenian Hamster anti-Mouse, eFluor 660, Clone: HMJ2-1, eBioscience™

Armenian Hamster Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 50-3392-80

Code: NEW

Additional Details:
Additional Details: Weight: 0.09500kg



Disclaimers: For Research Use Only.

Product Code. 15509936

Quantity Price
1 £ 60.53 / 25µg
Estimated Shipment date
from Supplier 09-05-2017
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Description and Specification

Specification

Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Host Species Armenian Hamster
Primary or Secondary Primary
Concentration 0.2mg/mL
Conjugate eFluor 660
Regulatory Status RUO
Clone HMJ2-1
Quantity 25μg
Isotype IgG
Format Conjugated
Species Reactivity Mouse, Rat
Applications Flow Cytometry
Gene Alias Jag2
Monoclonal or Polyclonal Monoclonal
Antigen Jagged 2
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer

This HMJ2-1 monoclonal antibody reacts with mouse Jagged-2, one of five type I transmembrane proteins that serves as a Notch receptor ligand. Upon binding the Notch receptor (e.g., Notch 1-4), Jagged-2 undergoes proteolytic cleavage, first by ADAM-family metalloproteases and then by gamma-secretase. The second cleavage event releases an intracellular fragment whose biological function remains controversial. Jagged-2 is expressed by thymic lymphoid and stromal cells, as well as macrophages and dendritic cells in the spleen.

Note: Staining of endogenous splenic dendritic (CD8+CD11c+) cells could only be consistently confirmed in cells isolated from C57BL/6, but not Balb/c, mice. Other strains have not been tested. The antiobdy has been reported to crossreact to rat and have blocking function.