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ITK, clone: 2F12, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 14-9752-82

Code : NEW

Additional Details : Weight : 0.09500kg

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Product Code. 15537636

  • £178.89 / 100µg


Estimated Shipment date
from Supplier 30-07-2018
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Description

Description

Description: The monoclonal antibody 2F12 recognizes human, mouse, and rat ITK. ITK (also known as Interleukin-2 inducible T-cell kinase, T-cell-specific kinase, Tyrosine-protein kinase Lyk, Emt, and Tsk) is a member of the Tec family of kinases that include Tec, Btk, Bmx, and Txk. Tec family kinases play an indispensable role in activation of phospholipase C and activation of calcium-dependent signaling cascades following antigen receptor triggering. ITK is highly expressed by T cells and is required for optimal TCR-induced PLCgamma1 activation. Mice congenitally lacking ITK show profound defects in T cell development and signaling. Defects in ITK are the cause of lymphoproliferative syndrome EBV-associated autosomal type 1 (LPSA1). ITK also plays a role in the development of various T cell mediated inflammatory disorders such as atopic dermatitis, psoriasis, and allergic asthma.Applications Reported: This 2F12 antibody has been reported for use in western blotting, immunohistochemical staining of formalin-fixed paraffin embedded tissue sections, and microscopy.Applications Tested: This 2F12 antibody has been tested by immunohistochemistry of formalin-fixed paraffin embedded human tissue using high pH antigen retrieval and can be used at less than or equal to 1 μg/mL. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.Purity: Greater than 90%, as determined by SDS-PAGE.Aggregation: Less than 10%, as determined by HPLC.Filtration: 0.2μm post-manufacturing filtered.
Specifications

Specifications

ITK
Monoclonal
0.5mg/mL
PBS with 0.09% sodium azide; pH 7.2
Q03526, Q08881
EMT, LYK, MGC126257, MGC126258, PSCTK2
Murine
Affinity chromatography
RUO
Antibody
Monoclonal
HumanþMurineþRat
ImmunohistochemistryþMicroscopyþWestern Blot
2F12
Unconjugated
ITK
Purified
Itk
IgG1, kappa
100μg
Store at 2-8°C.
Primary
3702
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