ITK Mouse, Clone: 2F12, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 14-9752-80

Code: NEW

Additional Details:
Additional Details: Weight: 0.09500kg



Disclaimers: For Research Use Only.

Product Code. 15527636

Quantity Price
1 £ 67.82 / 25µg
Estimated Shipment date
from Supplier 04-05-2017
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Description and Specification

Specification

Applications Immunohistochemistry (Formalin/Paraffin)
Applications Microscopy
Applications Western Blotting
Species Reactivity Human, Mouse, Rat
Primary or Secondary Primary
Quantity 25μg
Conjugate Unlabeled
Format Purified
Regulatory Status RUO
Storage Requirements Store at 2-8°C.
Clone 2F12
Antigen ITK
Concentration 0.5mg/mL
Gene Alias IL-2 inducible T-cell kinase
Isotype IgG1
Monoclonal or Polyclonal Monoclonal
Host Species Mouse
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer

The monoclonal antibody 2F12 recognizes human, mouse, and rat ITK. ITK (also known as Interleukin-2 inducible T-cell kinase, T-cell-specific kinase, Tyrosine-protein kinase Lyk, Emt, and Tsk) is a member of the Tec family of kinases that include Tec, Btk, Bmx, and Txk. Tec family kinases play an indispensable role in activation of phospholipase C and activation of calcium-dependent signaling cascades following antigen receptor triggering. ITK is highly expressed by T cells and is required for optimal TCR-induced PLCγ1 activation. Mice congenitally lacking ITK show profound defects in T cell development and signaling. Defects in ITK are the cause of lymphoproliferative syndrome EBV-associated autosomal type 1 (LPSA1). ITK also plays a role in the development of various T cell mediated inflammatory disorders such as atopic dermatitis, psoriasis, and allergic asthma.