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ITK Mouse, Clone: 2F12, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 14-9752-80

Code : NEW

Additional Details : Weight : 0.09500kg

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Product Code. 15527636

  • £67.82 / 25µg


Estimated Shipment date
from Supplier 29-08-2017
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Disclaimers:

For Research Use Only.


Specifications

Description

The monoclonal antibody 2F12 recognizes human, mouse, and rat ITK. ITK (also known as Interleukin-2 inducible T-cell kinase, T-cell-specific kinase, Tyrosine-protein kinase Lyk, Emt, and Tsk) is a member of the Tec family of kinases that include Tec, Btk, Bmx, and Txk. Tec family kinases play an indispensable role in activation of phospholipase C and activation of calcium-dependent signaling cascades following antigen receptor triggering. ITK is highly expressed by T cells and is required for optimal TCR-induced PLCγ1 activation. Mice congenitally lacking ITK show profound defects in T cell development and signaling. Defects in ITK are the cause of lymphoproliferative syndrome EBV-associated autosomal type 1 (LPSA1). ITK also plays a role in the development of various T cell mediated inflammatory disorders such as atopic dermatitis, psoriasis, and allergic asthma.
Description & Specifications

Specifications

ITK
2F12
Unlabeled
Purified
Murine
25μg
Store at 2-8°C.
Monoclonal
Western Blot
0.5mg/mL
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
IL-2 inducible T-cell kinase
IgG1
RUO
Primary
Rat