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ISG15 Armenian Hamster anti-Mouse, Clone: 3C2, eBioscience™

Armenian Hamster Monoclonal Antibody

Brand:  Affymetrix eBioscience 14-5857-82

UNSPSC : 12352200

Code : Z2

Additional Details : Weight : 0.01000kg

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Product Code. 15257517

  • £170.59 / 100µg


Estimated Shipment
02-11-2017
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Disclaimers:

For Research Use Only.


Description

Description

This 3C2 monoclonal antibody reacts with mouse interferon stimulated gene-15 (ISG-15), a 15kDa ubiquitin-like protein (UBL) and cytokine. ISG-15 is translated as a precursor that is subsequently activated by an E1 enzyme, conjugated by an E2 enzyme via the C-terminal LRLRGG motif and ligated by an E3 ligase. The activity of ISG-15 is dependent on its modification of target proteins at specific lysine residues. Several viruses utilize ISG-15 and ubiquitin deconjugating proteases, while influenza B protein NS1 has been shown to specifically bind ISG-15 thereby blocking its conjugation.

In addition to its role as a protein modification, ISG-15 is secreted by monocytes and lymphocytes in response to IFNα, β, or γ, as well as influenza B virus. In this role as cytokine, it has been shown to induce secretion of IFNγ and support NK cell proliferation and cytolytic activity.
Specifications

Specifications

ISG15
3C2
Unlabeled
Purified
Armenian Hamster
100μg
Store at 2-8°C.
Monoclonal
Western Blot
0.5mg/mL
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
ISG-15
IgG
RUO
Primary
Murine