missing translation for 'onlineSavingsMsg'
Learn More

ISG15 Armenian Hamster anti-Mouse, Clone: 3C2, eBioscience™

Armenian Hamster Monoclonal Antibody

Brand:  Affymetrix eBioscience 14-5857-80

UNSPSC : 12352200

Code : Z2

Additional Details : Weight : 0.01000kg

 View more versions of this product

Product Code. 15247517

  • £84.99 / 25µg


Call for latest availability
+44 (0)1509 555 500
Add to basket

Disclaimers:

For Research Use Only.


Specifications

Description

This 3C2 monoclonal antibody reacts with mouse interferon stimulated gene-15 (ISG-15), a 15kDa ubiquitin-like protein (UBL) and cytokine. ISG-15 is translated as a precursor that is subsequently activated by an E1 enzyme, conjugated by an E2 enzyme via the C-terminal LRLRGG motif and ligated by an E3 ligase. The activity of ISG-15 is dependent on its modification of target proteins at specific lysine residues. Several viruses utilize ISG-15 and ubiquitin deconjugating proteases, while influenza B protein NS1 has been shown to specifically bind ISG-15 thereby blocking its conjugation.

In addition to its role as a protein modification, ISG-15 is secreted by monocytes and lymphocytes in response to IFNα, β, or γ, as well as influenza B virus. In this role as cytokine, it has been shown to induce secretion of IFNγ and support NK cell proliferation and cytolytic activity.
Description & Specifications

Specifications

ISG15
3C2
Unlabeled
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Armenian Hamster
25μg
Store at 2-8°C.
Monoclonal
Western Blot
0.5mg/mL
Purified
ISG-15
IgG
RUO
Primary
Murine