ISG15 Armenian Hamster anti-Mouse, Clone: 3C2, eBioscience™

Armenian Hamster Monoclonal Antibody

Brand: Affymetrix eBioscience

Manufacturer Part Number: 14-5857-80

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.01000kg

Disclaimers: For Research Use Only.

Product Code. 15247517

Quantity Price
1 £ 84.99 / 25µg
Estimated Shipment date
from Supplier 05-05-2017
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Description and Specification


Gene Alias ISG-15
Quantity 25μg
Host Species Armenian Hamster
Antigen ISG15
Format Purified
Species Reactivity Mouse
Concentration 0.5mg/mL
Regulatory Status RUO
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Isotype IgG
Monoclonal or Polyclonal Monoclonal
Primary or Secondary Primary
Clone 3C2
Conjugate Unlabeled
Applications Western Blotting
Storage Requirements Store at 2-8°C.

This 3C2 monoclonal antibody reacts with mouse interferon stimulated gene-15 (ISG-15), a 15kDa ubiquitin-like protein (UBL) and cytokine. ISG-15 is translated as a precursor that is subsequently activated by an E1 enzyme, conjugated by an E2 enzyme via the C-terminal LRLRGG motif and ligated by an E3 ligase. The activity of ISG-15 is dependent on its modification of target proteins at specific lysine residues. Several viruses utilize ISG-15 and ubiquitin deconjugating proteases, while influenza B protein NS1 has been shown to specifically bind ISG-15 thereby blocking its conjugation.

In addition to its role as a protein modification, ISG-15 is secreted by monocytes and lymphocytes in response to IFNα, β, or γ, as well as influenza B virus. In this role as cytokine, it has been shown to induce secretion of IFNγ and support NK cell proliferation and cytolytic activity.