ISG15 Armenian Hamster anti-Mouse, Clone: 3C2, eBioscience™
Armenian Hamster Monoclonal Antibody
Brand: Affymetrix eBioscience 14-5857-80
UNSPSC : 12352200
Code : Z2
Additional Details : Weight : 0.01000kg
DescriptionThis 3C2 monoclonal antibody reacts with mouse interferon stimulated gene-15 (ISG-15), a 15kDa ubiquitin-like protein (UBL) and cytokine. ISG-15 is translated as a precursor that is subsequently activated by an E1 enzyme, conjugated by an E2 enzyme via the C-terminal LRLRGG motif and ligated by an E3 ligase. The activity of ISG-15 is dependent on its modification of target proteins at specific lysine residues. Several viruses utilize ISG-15 and ubiquitin deconjugating proteases, while influenza B protein NS1 has been shown to specifically bind ISG-15 thereby blocking its conjugation.
In addition to its role as a protein modification, ISG-15 is secreted by monocytes and lymphocytes in response to IFNα, β, or γ, as well as influenza B virus. In this role as cytokine, it has been shown to induce secretion of IFNγ and support NK cell proliferation and cytolytic activity.
|aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer|
|Store at 2-8°C.|