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IRF8 Mouse anti-Human, Mouse, PerCP-eFluor 710, Clone: V3GYWCH, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 46-9852-82

Code : NEW

Additional Details : Weight : 0.09500kg

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Product Code. 15599436

  • £212.40 / 100µg


EU Stock 3
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Disclaimers:

For Research Use Only.


Description

Description

The V3GYWCH monoclonal antibody reacts with human and mouse interferon regulatory factor 8 (IRF8; ICSBP). IRF8 is a 50kDa transcription factor that plays a critical role in the development of dendritic cells (DC). Specifically, IRF8 is essential in the development and differentiation of plasmacytoid DC (pDC) and CD8a+ DC. IRF8-/- mice are deficient in both pDC and CD8a+ DC populations. CD8a- DC are present in normal numbers in IRF8-/- mice but fail to mature upon Toll-like receptor signaling and are functionally impaired in response to in vivo microbial stimulation. IRF8 deficiency does not affect the frequency or viability of DC precursors and as a result retroviral IRF8 transduction restores pDC development from DC progenitors in IRF8-/- mice.
Specifications

Specifications

IRF8
V3GYWCH
PerCP-eFluor 710
Conjugated
IgG1
RUO
Primary
Murine
Flow Cytometry (Intracellular Staining)
0.2mg/mL
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Murine
100μg
Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal