IRF7 Rat anti-Mouse, PE, Clone: MNGPKL, eBioscience™

Rat Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 12-5829-80

Code: NEW

Additional Details:
Additional Details: Weight: 0.09500kg



Disclaimers: For Research Use Only.

Product Code. 15577026

Quantity Price
1 £ 66.65 / 25µg
Estimated Shipment date
from Supplier 10-05-2017
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Description and Specification

Specification

Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Gene Alias Interferon Regulatory Factor 7
Species Reactivity Mouse
Clone MNGPKL
Applications Flow Cytometry (Intracellular Staining)
Conjugate PE
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Concentration 0.2mg/mL
Regulatory Status RUO
Isotype IgG2a
Format Conjugated
Antigen IRF7
Host Species Rat
Quantity 25μg

The monoclonal antibody MNGPKL reacts with mouse interferon regulatory factor 7 (IRF7), a 54kDa transcription factor essential for induction of the antiviral innate immune response and IFN alpha production. B cells, plasmacytoid dendritic cells (pDC), and monocytes constitutively express IRF7 in the cytoplasm until activation by viral infection, double-stranded RNA or Toll-like receptor (TLR) signaling. CpG ODNs and single-stranded RNA, recognized by CD289 (TLR9) and TLR7, respectively, trigger IRF7 activation and upregulation. This activation promotes type I IFN response to disrupt pathogen and viral infection. These events cause IRF7 phosphorylation and translocation to the nucleus where it forms a homodimer to affect transcription.