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IRF7 Rat anti-Mouse, PE, Clone: MNGPKL, eBioscience™

Rat Monoclonal Antibody

Brand:  Affymetrix eBioscience 12-5829-80

Code : NEW

Additional Details : Weight : 0.09500kg

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Product Code. 15577026

  • £66.65 / 25µg


EU Stock 1
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Disclaimers:

For Research Use Only.


Description

Description

The monoclonal antibody MNGPKL reacts with mouse interferon regulatory factor 7 (IRF7), a 54kDa transcription factor essential for induction of the antiviral innate immune response and IFN alpha production. B cells, plasmacytoid dendritic cells (pDC), and monocytes constitutively express IRF7 in the cytoplasm until activation by viral infection, double-stranded RNA or Toll-like receptor (TLR) signaling. CpG ODNs and single-stranded RNA, recognized by CD289 (TLR9) and TLR7, respectively, trigger IRF7 activation and upregulation. This activation promotes type I IFN response to disrupt pathogen and viral infection. These events cause IRF7 phosphorylation and translocation to the nucleus where it forms a homodimer to affect transcription.
Specifications

Specifications

IRF7
MNGPKL
PE
Conjugated
Rat
25μg
Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal
Flow Cytometry (Intracellular Staining)
0.2mg/mL
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Interferon Regulatory Factor 7
IgG2a
RUO
Primary
Murine