IRF5 Mouse anti-Human, eFluor 660, Clone: ALYSCLN, eBioscience™
Mouse Monoclonal Antibody
Brand: Affymetrix eBioscience 50-9698-41
Code : NEW
Additional Details : Weight : 0.23750kg
DescriptionThe ALYSCLN monoclonal antibody reacts with human IRF5, a 60-63kDa member of the interferon regulatory factor family of transcription factors that have diverse roles in host defense against viruses. IRF5 was originally identified as an important regulator of IFN alpha and IFN beta and more recently has been shown to be regulated by these interferons. IRF5 is also involved in induction of pro-inflammatory cytokines including IL-6, IL-12 and TNF alpha in response to TLR signaling. Specifically, it has been shown that MyD88 and TRAF6 interact directly with IRF5 in response to TLR activation and this interaction results in IRF5 nuclear translocation. Additionally, IRF5 has been shown to have both p53-dependent and independent effects in regulation of cell cycle and apoptosis. Genetic polymorphisms in the IRF5 locus have been implicated in many autoimmune diseases including Sjogren’s syndrome, inflammatory bowel disease, multiple sclerosis and systemic lupus erythematosus.
Recently, a role for IRF5 in the polarization of classically activated (M1) macrophages has been identified. In these macrophages, IRF5 directly upregulates expression of IL-12 and IL-23 and represses IL-10. Moreover, exogenous expression of IRF5 in M2-polarized (alternatively activated) macrophages induces expression of M1-related cytokines and chemokines. IRF5 is expressed at highest levels in monocytes, macrophages and plasmacytoid dendritic cells, but is also expressed in B cells and T cells.
|aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer|
|Flow Cytometry (Intracellular Staining)|
|Store at 2-8°C. Do not freeze. Light-sensitive material.|