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IRF4 Rat anti-Human, Mouse, PerCP-eFluor 710, Clone: 3E4, eBioscience™

Rat Monoclonal Antibody

Brand:  Affymetrix eBioscience 46-9858-80

Code : NEW

Additional Details : Weight : 0.09500kg

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Product Code. 15569446

  • £84.69 / 25µg


EU Stock 5
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Disclaimers:

For Research Use Only.


Specifications

Description

The monoclonal antibody 3E4 reacts with human and mouse interferon regulatory factor 4 (IRF4). IRF4 is a 52kDa transcription factor with roles in B cell, T cell and macrophage function. In B cells, IRF4 is highly expressed in mature plasma cells and plays a crucial role in their differentiation. IRF4 has been shown to interact with PU.1 and control the transcription of many B cell-specific genes including Prdm1, which encodes Blimp1. In T cells, IRF4 has been implicated in regulatory T (Treg), Th2, Th9 and Th17 cell development and function. This transcription factor is upregulated upon T cell activation and is expressed in mature T cells. Studies have shown that IRF4 directly induces Blimp1 expression in Tregs, leading to IL-10 expression. IRF4 has also been demonstrated to be involved in macrophage polarization and regulation. Lastly, in addition to its roles in normal immune function, IRF4 expression has been reported to be upregulated in many blood-related cancers.
Description & Specifications

Specifications

IRF4
3.00E+04
PerCP-eFluor 710
Conjugated
Rat
25μg
Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal
Flow Cytometry (Intracellular Staining)
0.2mg/mL
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Interferon regulatory factor 4
IgG1
RUO
Primary
Murine