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Integrin alpha 4 beta 7 (LPAM-1) Rat anti-Mouse, Biotin, Clone: DATK32 (DATK-32), eBioscience™

Rat Monoclonal Antibody

Brand:  Affymetrix eBioscience 13-5887-81

Code : Z2

Additional Details : Weight : 0.25000kg

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Product Code. 15229899

  • £48.89 / 50µg


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Disclaimers:

For Research Use Only.


Description

Description

The DATK32 monoclonal antibody binds to a combinatorial epitope of mouse LPAM-1 (α4β7), which is a heterodimer of the the 154kDa α4 subunit and the 130kDa β7 subunit. In mouse, the β7 subunit is found on the majority of mature lymphocytes and a small population of thymocytes and bone marrow cells. LPAM-1 is an integrin involved in the transendothelial migration of lymphocytes across high endothelial venules (HEV), and is know to bind several ligands including MAdCAM-1, VCAM-1 and fibronectin. Binding of the DATK32 monoclonal antibody has been shown to induce aggregation of the CD8+ T cell lymphoma TK1, and block LPAM-1-mediated cell adhesion.
Specifications

Specifications

Integrin alpha 4 beta 7 (LPAM-1)
DATK32 (DATK-32)
Biotin
Conjugated
IgG2a
RUO
Primary
Murine
Flow Cytometry
0.5mg/mL
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Rat
50μg
Store at 2-8°C. Do not freeze.
Monoclonal
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