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Tocris Bioscience™ Indibulin

Microtubule destabilizer

Brand:  Tocris Bioscience™ 372850

Code : Z1

Additional Details : Weight : 0.01000kg

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Product Code. 13443504

  • £578.53 / 50mg

Estimated Shipment date
from Supplier 01-10-2019

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Description

Description

Microtubule destabilizer that blocks tubulin polymerization (IC50 = 0.3 μM). Blocks cell cycle progression at metaphase and displays antitumor activity against a variety of malignancies in vitro (IC50 values ranging from 0.036 - 0.285 μM). Induces complete tumor remission in the Yoshida AH13 rat sarcoma model in vivo. Lacks neurotoxicity due to an ability to discriminate between posttranslationally modified tubulin in mature neuronal microtubules and less-modified tubulin present in immature neuronal or nonneuronal microtubules. Displays oral availability and efficacy towards MDR tumor cells.
Specifications

Specifications

Indibulin
>98
50mg
Indibulin
389.83
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