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IL-9 Rat anti-Mouse, eFluor 660, Clone: RM9A4, eBioscience™

Rat Monoclonal Antibody

Brand:  Affymetrix eBioscience 50-8091-80

Code : Z2

Additional Details : Weight : 0.25000kg

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Product Code. 15341960

  • £78.88 / 25µg


Estimated Shipment date
from Supplier 20-12-2017
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Disclaimers:

For Research Use Only.


Description

Description

This monoclonal RM9A4 antibody reacts with mouse Interleukin-9 (IL-9). IL-9 is a 14kDa cytokine originally named P40 and identified by its proliferative effects on T cell populations. The receptor, which is a heterodimer of the gamma chain portion of the IL-2 receptor and the IL-9R chain, activates Jak/STAT signaling pathways upon binding its ligand. Since the discovery of IL-9, numerous other functions have been observed. It induces Th17 and Treg differentiation in CD4+ T cells, IgE production in B cells, and the differentiation and proliferation of mast cells. IL-9 expression was initially observed in Th2 cells, but has since been found in Th17, eosinophil, and mast cells. Th9 cells, a newly discovered subset of CD4+ T cells, are characterized by the secretion of large amounts of IL-9 and IL-10. Th9 development is induced by stimulation of undifferentiated CD4+ with IL-4 and TGF beta. Th2 cells can also be driven towards a Th9 phenotype in the presence of TGF beta.
Specifications

Specifications

IL-9
RM9A4
eFluor 660
Conjugated
Rat
25μg
Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal
Flow Cytometry (Intracellular Staining)
0.2mg/mL
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Interleukin-9, Cytokine P40
IgG1
RUO
Primary
Murine
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