IL-9 Rat anti-Mouse, eFluor 660, Clone: RM9A4, eBioscience™

Rat Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 50-8091-82

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.25000kg



Disclaimers: For Research Use Only.

Product Code. 15351960

Quantity Price
1 £ 201.16 / 100µg
Estimated Shipment date
from Supplier 03-05-2017
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Description and Specification

Specification

Quantity 100μg
Applications Flow Cytometry (Intracellular Staining)
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Host Species Rat
Regulatory Status RUO
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Conjugate eFluor 660
Species Reactivity Mouse
Antigen IL-9
Format Conjugated
Concentration 0.2mg/mL
Gene Alias Interleukin-9, Cytokine P40
Isotype IgG1
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Clone RM9A4

This monoclonal RM9A4 antibody reacts with mouse Interleukin-9 (IL-9). IL-9 is a 14kDa cytokine originally named P40 and identified by its proliferative effects on T cell populations. The receptor, which is a heterodimer of the gamma chain portion of the IL-2 receptor and the IL-9R chain, activates Jak/STAT signaling pathways upon binding its ligand. Since the discovery of IL-9, numerous other functions have been observed. It induces Th17 and Treg differentiation in CD4+ T cells, IgE production in B cells, and the differentiation and proliferation of mast cells. IL-9 expression was initially observed in Th2 cells, but has since been found in Th17, eosinophil, and mast cells. Th9 cells, a newly discovered subset of CD4+ T cells, are characterized by the secretion of large amounts of IL-9 and IL-10. Th9 development is induced by stimulation of undifferentiated CD4+ with IL-4 and TGF beta. Th2 cells can also be driven towards a Th9 phenotype in the presence of TGF beta.