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IL-8 Mouse anti-Human, eFluor 450, Clone: 8CH, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 48-8088-41

Code : NEW

Additional Details : Weight : 0.23750kg

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Product Code. 15589816

  • £78.88 / 25 tests


Estimated Shipment date
from Supplier 26-09-2017
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Disclaimers:

For Research Use Only.


Description

Description

This 8CH monoclonal antibody reacts with human IL-8 (CXCL8), a pro-inflammatory CXC chemokine. It is synthesized as a 99 amino acid precursor protein that is further processed into one of four isoforms, with the most common being 72 or 77 amino acids in length. IL-8(77) is secreted primarily by endothelial cells and is thought to be a less potent neutrophil activator than the other forms. It is present at high levels during fetal development, where it mediates angiogenesis rather than inflammation. The predominant form present in adults is IL-8(72), which is expressed by monocytes, macrophages, epithelial cells, and fibroblasts in response to inflammatory stimuli, environmental stress, and steroid hormones. IL-8(72) is essential for the activation and recruitment of neutrophils to sites of inflammation, and has also been found to influence T cell migration. Signaling occurs through the G-protein coupled receptors CXCR1 or CXCR2. IL-8 transcripts are often upregulated in tumors, and it is associated with tumor angiogenesis and metastasis.
Specifications

Specifications

IL-8
8CH
eFluor 450
Conjugated
Murine
25 Tests
Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal
Flow Cytometry (Intracellular Staining)
5μL (0.06μg)/test
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Interleukin-8, CXCL8, NAP-I
IgG1
RUO
Primary
Human