IL-8 Mouse anti-Human, eFluor 450, Clone: 8CH, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 48-8088-41

Code: NEW

Additional Details:
Additional Details: Weight: 0.23750kg



Disclaimers: For Research Use Only.

Product Code. 15589816

Quantity Price
1 £ 78.88 / 25 tests
Estimated Shipment date
from Supplier 05-05-2017
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Description and Specification

Specification

Host Species Murine
Quantity 25 Tests
Species Reactivity Human
Applications Flow Cytometry (Intracellular Staining)
Isotype IgG1
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Clone 8CH
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Format Conjugated
Primary or Secondary Primary
Regulatory Status RUO
Gene Alias Interleukin-8, CXCL8, NAP-I
Conjugate eFluor 450
Antigen IL-8
Monoclonal or Polyclonal Monoclonal
Concentration 5μL (0.06μg)/test

This 8CH monoclonal antibody reacts with human IL-8 (CXCL8), a pro-inflammatory CXC chemokine. It is synthesized as a 99 amino acid precursor protein that is further processed into one of four isoforms, with the most common being 72 or 77 amino acids in length. IL-8(77) is secreted primarily by endothelial cells and is thought to be a less potent neutrophil activator than the other forms. It is present at high levels during fetal development, where it mediates angiogenesis rather than inflammation. The predominant form present in adults is IL-8(72), which is expressed by monocytes, macrophages, epithelial cells, and fibroblasts in response to inflammatory stimuli, environmental stress, and steroid hormones. IL-8(72) is essential for the activation and recruitment of neutrophils to sites of inflammation, and has also been found to influence T cell migration. Signaling occurs through the G-protein coupled receptors CXCR1 or CXCR2. IL-8 transcripts are often upregulated in tumors, and it is associated with tumor angiogenesis and metastasis.