IL-8 Mouse anti-Human, APC, Clone: 8CH, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 17-8088-41

Code: NEW

Additional Details:
Additional Details: Weight: 0.23750kg



Disclaimers: For Research Use Only.

Product Code. 15538206

Quantity Price
1 £ 78.88 / 25 tests
EU Stock 1
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Description and Specification

Specification

Format Conjugated
Isotype IgG1
Conjugate APC
Species Reactivity Human
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Primary or Secondary Primary
Applications Flow Cytometry (Intracellular Staining)
Host Species Mouse
Regulatory Status RUO
Antigen IL-8
Concentration 5μL (0.015μg)/test
Monoclonal or Polyclonal Monoclonal
Clone 8CH
Gene Alias Interleukin-8, CXCL8, NAP-I
Quantity 25 tests
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.

This 8CH monoclonal antibody reacts with human IL-8 (CXCL8), a pro-inflammatory CXC chemokine. It is synthesized as a 99 amino acid precursor protein that is further processed into one of four isoforms, with the most common being 72 or 77 amino acids in length. IL-8(77) is secreted primarily by endothelial cells and is thought to be a less potent neutrophil activator than the other forms. It is present at high levels during fetal development, where it mediates angiogenesis rather than inflammation. The predominant form present in adults is IL-8(72), which is expressed by monocytes, macrophages, epithelial cells, and fibroblasts in response to inflammatory stimuli, environmental stress, and steroid hormones. IL-8(72) is essential for the activation and recruitment of neutrophils to sites of inflammation, and has also been found to influence T cell migration. Signaling occurs through the G-protein coupled receptors CXCR1 or CXCR2. IL-8 transcripts are often upregulated in tumors, and it is associated with tumor angiogenesis and metastasis.