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IL-4 Mouse anti-Human, APC, Clone: 8D4-8, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 17-7049-41

Code : NEW

Additional Details : Weight : 0.23750kg

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Product Code. 15538186

  • £60.50 / 25 tests

Estimated Shipment: 28-09-2021

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Description

Description

Description: The 8D4-8 antibody reacts with human interleukin-4 (IL-4), a 15-19 kDa cytokine secreted by Th2 cells. Applications Reported: The 8D4-8 antibody has been reported for use as a capture antibody for human IL-4 ELISA and for intracellular staining for flow cytometric analysis. Applications Tested: This 8D4-8 antibody has been tested in intracellular staining and flow cytometric analysis of stimulated human peripheral blood cells. This can be used at less than or equal to 0.125 μg per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Excitation: 633-647 nm; Emission: 660 nm; Laser: Red Laser. Filtration: 0.2 μm post-manufacturing filtered.

Interleukin-4 (IL-4) is a pleiotropic, immune-modulatory cytokine produced by activated T cells, and serves as a ligand for interleukin 4 receptor. IL-4 has been found to have the broadest range of actions. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play an important role in mediating the immune regulatory signal of IL-4. The IL-4 gene, IL-3, IL-5, IL-13, and CSF2 form a cytokine gene cluster on chromosome 5q. In particular, IL-4 is located in close proximity to IL13 on the chromosome. Further, the IL-4 gene, IL13 and IL5 are found to be coordinated by several long-range regulatory elements over a 120 kilobase range on the chromosome. IL-4 delta 2 is a known splice variant of IL-4.
Specifications

Specifications

IL-4
Monoclonal
5 μL/Test
PBS with 0.1% gelatin, 0.2% BSA and 0.09% sodium azide; pH 7.2
P05112
Interleukin-4, BSF1, IL-4, Lymphocyte stimulatory factor 1, MGC79402
Mouse
Affinity chromatography
RUO
Antibody
Monoclonal
Human
Flow Cytometry
8D4-8
APC
IL4
Liquid
IL4
IgG1, kappa
25 Tests
4° C, store in dark, DO NOT FREEZE!
Primary
3565
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For Research Use Only.