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IL-38 Monoclonal Antibody (H127C), Biotin, eBioscience™, Invitrogen™

Mouse Monoclonal Antibody

£89.00 - £240.00

Specifications

Antigen IL-38
Clone H127C
Classification Monoclonal
Conjugate Biotin
Form Liquid
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Products 2
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Product Code Brand Quantity Price Quantity & Availability  
15527356
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Affymetrix eBioscience
13-7385-82
100 μg
£240.00
100µg
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15517356
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Affymetrix eBioscience
13-7385-80
25 μg This item is currently unavailable or has been discontinued.
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Description

Description

Description: The monoclonal antibody H127C recognizes human IL-38. IL-38 is a member of the Interleukin-1 family (IL-1F) and shares homology with IL-1R antagonist (IL-1Ra) and IL-36R antagonist (IL-36Ra). IL-38 is expressed mostly in the skin and proliferating B cells of the tonsil and is also present at low levels in the heart and placenta. IL-38 functions as an anti-inflammatory cytokine that inhibits IL-36 by binding to IL-36R and also inhibits the production of IL-17 and IL-22. Gene polymorphisms of IL-38 are associated with psoriatic arthritis, ankylosing spondylitis, and heart disease. Applications Reported: This H127C antibody has been reported for use in immunohistochemical staining of formalin-fixed paraffin embedded tissue sections. Applications Tested: This H127C antibody has been tested tested by immunohistochemistry on human FFPE tissue using low pH antigen retrieval and can be used at less than or equal to 5 μg/mL. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Filtration: 0.2 μm post-manufacturing filtered.

The cytokine IL-1 is responsible for initiating a variety of activities through the activation of transcription factors, NF-kappa B and AP-1, thereby promoting host response to injury or infection. IL-1F10 (Interleukin-1 family member 10), also known as FIL1T, IL1HY2 or FKSG75, is highly expressed in the skin, spleen and proliferating B-cells of the tonsil. IL-1F10 binds soluble IL-1 receptor type 1, and is one of nine Interleukin 1 families clustered on chromosome 2, where it is thought to participate in the regulation of adapted and innate immune responses. IL-1F10 and IL-1RN polymorphisms may play an important role in the susceptibility to developing rheumatoid arthritis.
Specifications

Specifications

IL-38
Monoclonal
Liquid
RUO
Q8WWZ1
IL1F10
Primary
Antibody
H127C
Biotin
Mouse
Human
84639
IgG2b κ
Affinity chromatography
IL1F10
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SDS
Documents

Documents

Product Certifications

For Research Use Only.