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IL-37 (IL-1F7) Mouse anti-Human, PE, Clone: 37D12, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 12-7379-42

Code : NEW

Additional Details : Weight : 0.23750kg

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Product Code. 15547126

  • £250.07 / 100 tests


Estimated Shipment date
from Supplier 03-08-2017
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Disclaimers:

For Research Use Only.


Specifications

Description

This 37D12 monoclonal antibody reacts with human IL-37. IL-37 is a member of the interleukin 1 cytokine family and is also known as IL-1F7 and IL-1H4. IL-37 suppresses innate inflammatory and immune responses and exhibits anti-inflammatory characteristics resembling those of IL-1R8. IL-37 binds to the alpha chain of IL-18R with low affinity and does not recruit the essential signaling co-receptor IL-18 beta or mediate pro-inflammatory activity. IL-37 also binds to IL-18 binding protein (IL-18BP) and enhances the antagonistic effects of IL-18BP. IL-37 forms a trimeric complex with IL-18BP and IL-18R beta, which results in the blockade of IL-18 activity. Transcripts of IL-37 have been detected in human tissues, such as lung, testis, and colon tumors, as well as some human cell lines.
Description & Specifications

Specifications

IL-37 (IL-1F7)
37D12
PE
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Murine
100 Tests
Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal
Flow Cytometry (Intracellular Staining)
5μL (0.06μg)/test
Conjugated
Interleukin-37, IL-1H4
IgG1
RUO
Primary
Human