IL-37 (IL-1F7) Mouse anti-Human, Clone: 37D12, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 14-7379-82

Code: NEW

Additional Details:
Additional Details: Weight: 0.09500kg



Disclaimers: For Research Use Only.

Product Code. 15527476

Quantity Price
1 £ 167.38 / 100µg
Estimated Shipment date
from Supplier 04-05-2017
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Description and Specification

Specification

Conjugate Unlabeled
Regulatory Status RUO
Antigen IL-37 (IL-1F7)
Gene Alias Interleukin-37, IL-1H4
Isotype IgG1
Monoclonal or Polyclonal Monoclonal
Quantity 100μg
Host Species Mouse
Applications Immunocytochemistry
Primary or Secondary Primary
Storage Requirements Store at 2-8°C.
Format Purified
Species Reactivity Human
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.5mg/mL
Clone 37D12

This 37D12 monoclonal antibody reacts with human IL-37. IL-37 is a member of the interleukin 1 cytokine family and is also known as IL-1F7 and IL-1H4. IL-37 suppresses innate inflammatory and immune responses and exhibits anti-inflammatory characteristics resembling those of IL-1R8. IL-37 binds to the alpha chain of IL-18R with low affinity and does not recruit the essential signaling co-receptor IL-18 beta or mediate pro-inflammatory activity. IL-37 also binds to IL-18 binding protein (IL-18BP) and enhances the antagonistic effects of IL-18BP. IL-37 forms a trimeric complex with IL-18BP and IL-18R beta, which results in the blockade of IL-18 activity. Transcripts of IL-37 have been detected in human tissues, such as lung, testis, and colon tumors, as well as some human cell lines.