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IL-37, Biotin, clone: 37D12, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 13-7379-80

Code : NEW

Additional Details : Weight : 0.09500kg

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Product Code. 15597346

  • £77.04 / 25µg


Estimated Shipment date
from Supplier 04-04-2018
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Description

Description

Description: This 37D12 monoclonal antibody reacts with human IL-37. IL-37 is a member of the interleukin 1 cytokine family and is also known as IL-1F7 and IL-1H4. IL-37 suppresses innate inflammatory and immune responses and exhibits anti-inflammatory characteristics resembling those of IL-1R8. IL-37 binds to the alpha chain of IL-18R with low affinity and does not recruit the essential signaling co-receptor IL-18 beta or mediate pro-inflammatory activity. IL-37 also binds to IL-18 binding protein (IL-18BP) and enhances the antagonistic effects of IL-18BP. IL-37 forms a trimeric complex with IL-18BP and IL-18R beta, which results in the blockade of IL-18 activity. Transcripts of IL-37 have been detected in human tissues, such as lung, testis, and colon tumors, as well as some human cell lines.Applications Reported: This 37D12 antibody has been reported for use in immunocytochemistry followed by cytospin.Applications Tested: This 37D12 antibody has been tested by immunocytochemistry of fixed and permeabilized normal human peripheral blood mononuclear cells and can be used at less than or equal to 20 μg/mL. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.Filtration: 0.2μm post-manufacturing filtered.
Specifications

Specifications

IL-37 (IL-1F7)
37D12
Biotin
Conjugated
Murine
25μg
Store at 2-8°C. Do not freeze.
Monoclonal
Immunocytochemistry
0.5mg/mL
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Interleukin-37, IL-1H4
IgG1, kappa
RUO
Primary
Human
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