IL-37 (IL-1F7) Mouse anti-Human, Biotin, Clone: 37D12, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 13-7379-82

Code: NEW

Additional Details:
Additional Details: Weight: 0.09500kg



Disclaimers: For Research Use Only.

Product Code. 15507356

Quantity Price
1 £ 180.2 / 100µg
Estimated Shipment date
from Supplier 02-05-2017
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Description and Specification

Specification

Regulatory Status RUO
Host Species Mouse
Concentration 0.5mg/mL
Isotype IgG1
Applications Immunocytochemistry
Antigen IL-37 (IL-1F7)
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Species Reactivity Human
Storage Requirements Store at 2-8°C. Do not freeze.
Clone 37D12
Format Conjugated
Primary or Secondary Primary
Quantity 100μg
Conjugate Biotin
Gene Alias Interleukin-37, IL-1H4
Monoclonal or Polyclonal Monoclonal

This 37D12 monoclonal antibody reacts with human IL-37. IL-37 is a member of the interleukin 1 cytokine family and is also known as IL-1F7 and IL-1H4. IL-37 suppresses innate inflammatory and immune responses and exhibits anti-inflammatory characteristics resembling those of IL-1R8. IL-37 binds to the alpha chain of IL-18R with low affinity and does not recruit the essential signaling co-receptor IL-18 beta or mediate pro-inflammatory activity. IL-37 also binds to IL-18 binding protein (IL-18BP) and enhances the antagonistic effects of IL-18BP. IL-37 forms a trimeric complex with IL-18BP and IL-18R beta, which results in the blockade of IL-18 activity. Transcripts of IL-37 have been detected in human tissues, such as lung, testis, and colon tumors, as well as some human cell lines.