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IL-27 p28 Monoclonal Antibody (3D1p28), eFluor™ 660, eBioscience™, Invitrogen™
Mouse Monoclonal Antibody
Brand: Affymetrix eBioscience 50-8277-42
Code : NEW
Additional Details : Weight : 0.23750kg
Description
Description: This 3D1p28 monoclonal antibody reacts with the human p28 subunit of IL-27. Interleukin-27 (IL-27) is a member of the IL-12 family, a subgroup of the IL-6 family of cytokines. It is a heterodimer of the subunits EBI3 (Epstein-Barr Virus Induced Gene 3), which is homologous to the p40 subunit shared by IL-12 and IL-23, and p28 (IL-30), which is homologous to p35. IL-27 is produced by activated dendritic cells and macrophages in response to TLR ligands and inflammatory cytokines. IL-27 has been shown to have both pro-inflammatory and anti-inflammatory effects. It influences the commitment of CD4+ T-cells toward the Th1 lineage by inducing the expression of the transcription factor T-bet and the upregulation of IL-12R beta2. Its anti-inflammatory functions include the suppression of Th2 and Th17 proliferation and differentiation. The IL-27 receptor shares one subunit, gp130, with other members of the IL-6 family. The subunit WSX-1 (IL-27R alpha, TCCR) is unique to IL-27 and is believed to be the only part of the receptor that interacts with the cytokine. IL-27R activation leads to the phosphorylation of Jak/STAT proteins, with STAT1 and STAT3 being critical to the function of IL-27. Recent evidence suggests that the p28 subunit may also be secreted independently of EBI3 and have functions distinct from the IL-27 heterodimer: it is believed to not only antagonize the activity of IL-27, but also inhibit signaling of other gp130 ligands, such as IL-6 and IL-11.
IL-27 p28 Monoclonal antibody specifically detects IL-27 p28 in Human samples. It is validated for Flow Cytometry.Specifications
IL-27 p28 | |
Monoclonal | |
5 μL/Test | |
PBS with 0.2% BSA and 0.09% sodium azide; pH 7.2 | |
Q8NEV9 | |
Il27 | |
Recombinant IL-27 | |
100 Tests | |
Primary | |
Human | |
Antibody | |
IgG1 κ |
Flow Cytometry | |
3D1p28 | |
eFluor 660 | |
Il27 | |
IL27; IL-27; IL-27 p28 subunit; IL-27 subunit alpha; Il27a; IL-27A; IL-27-A; IL27-A; IL27p28; IL-27p28; IL30; IL-30; ILN; Interleukin; interleukin 27; interleukin 30; Interleukin-27; interleukin-27 subunit alpha; Interleukin-30; p28 | |
Mouse | |
Affinity chromatography | |
RUO | |
246778 | |
4° C, store in dark, DO NOT FREEZE! | |
Liquid |
For Research Use Only.