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IL-23 Rat anti-Mouse, PerCP-eFluor 710, Clone: fc23cpg, eBioscience™

Rat Monoclonal Antibody

Brand:  Affymetrix eBioscience 46-7023-82

Code : NEW

Additional Details : Weight : 0.09500kg

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Product Code. 15579336

  • £227.17 / 100µg


Estimated Shipment date
from Supplier 27-10-2017
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Disclaimers:

For Research Use Only.


Description

Description

This fc23cpg monoclonal antibody reacts with the p19 subunit of mouse IL-23, a heterodimeric cytokine made up of two disulfide-linked subunits, p40 and p19. It is closely related to IL-12, with which it shares the p40 subunit. IL-23 signals through a heterodimeric receptor expressed on activated T cells, macrophages, and dendritic cells. The receptor shares the IL-12Rβ1 chain with IL-12, while the IL-23R chain is unique to the IL-23 receptor complex. Binding of IL-23 to its receptor activates Jak/STAT pathways similarly to IL-12, but the two cytokines exhibit distinct functions. Unlike IL-12, which induces T-bet and Th1 differentiation, IL-23 signaling results in RORγt expression and supports CD4+ T cells with the Th17 phenotype.

Dendritic cells and macrophages produce IL-23 in response to TLR2, TLR4, and TLR8 ligands, as well as agonists of the β-glucan receptor, Dectin-1. Our studies suggest donor, kinetics and type of stimulant can result in variation in IL-23 expression levels. Recent publications suggest the p19 subunit may also exist in the absence of association with p40.
Specifications

Specifications

IL-23
fc23cpg
PerCP-eFluor 710
Conjugated
Rat
100μg
Store at 2-8°C. Do not freeze. Light-sensitive material. This tandem dye is sensitive to photo-induced oxidation. Protect this vial from light during storage
Monoclonal
Flow Cytometry (Intracellular Staining)
0.2mg/mL
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Interleukin-23 p19
IgG1
RUO
Primary
Murine