IL-23 p19 Mouse anti-Human, Clone: HNU2319, Functional Grade, eBioscience™

Mouse Monoclonal Antibody, Functional Grade

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 16-5236-82

100UG:ANTI-HUMAN IL-23 P19 FUNCTIONAL GRADE

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.01000kg



Disclaimers: For Research Use Only.

Product Code. 15298637

Quantity Price
1 £ 95.0 / 100µg
Estimated Shipment date
from Supplier 09-12-2016
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Description and Specification

Specification

Antigen IL-23 p19
Applications Cytokine Neutralization
Clone HNU2319
Concentration 1mg/mL
Conjugate Unlabeled
Format Purified
Formulation aqueous buffer, no sodium azide
Gene Alias Interleukin 23 p19, IL23 p19, IL23p19, IL-23p19
Host Species Mouse
Isotype IgG1
Quantity 100μg
Regulatory Status RUO
Species Reactivity Human
Storage Requirements Store at 2-8°C.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal

The HNU2319 monoclonal antibody is specific to the p19 subunit of human IL-23, a heterodimeric cytokine made up of two covalently linked subunits, p40 and p19. It is closely related to IL-12, with which it shares the p40 subunit. Dendritic cells and macrophages produce IL-23 in response to TLR2, TLR4, and TLR8 ligands, as well as the β-glucan receptor Dectin-1.

Human IL-23 induces proliferation of memory T cells and induces moderate levels of IFN-γ production by naïve and memory T cells, as compared to IL-12. In contrast, the mouse IL-23 biological activities are more distinctly different than those of mouse IL-12 suggesting the signaling or response elements (receptors) differ between species. The IL-23 receptor is also heterodimeric and shares the IL-12Rβ1 chain with IL-12, while the IL-23R chain is unique to IL-23. Signaling occurs through the Jak/STAT pathway and results in RORγt expression, which drives the differentiation of CD4+ T-cells towards the Th17 phenotype.

The monoclonal antibody HNU2319 neutralizes the bioactivity of IL-23 without affecting IL-12.