IL-23 p19 Mouse anti-Human, Clone: HNU2319, Functional Grade, eBioscience™

Mouse Monoclonal Antibody, Functional Grade

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 16-5236-85

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.01000kg



Disclaimers: For Research Use Only.

Product Code. 15208647

Quantity Price
1 £ 170.59 / 500µg
Estimated Shipment date
from Supplier 30-03-2017
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Description and Specification

Specification

Format Purified
Isotype IgG1
Clone HNU2319
Monoclonal or Polyclonal Monoclonal
Species Reactivity Human
Conjugate Unlabeled
Primary or Secondary Primary
Gene Alias Interleukin 23 p19, IL23 p19, IL23p19, IL-23p19
Applications Cytokine Neutralization
Antigen IL-23 p19
Formulation aqueous buffer, no sodium azide
Concentration 1mg/mL
Host Species Mouse
Storage Requirements Store at 2-8°C.
Quantity 500μg
Regulatory Status RUO

The HNU2319 monoclonal antibody is specific to the p19 subunit of human IL-23, a heterodimeric cytokine made up of two covalently linked subunits, p40 and p19. It is closely related to IL-12, with which it shares the p40 subunit. Dendritic cells and macrophages produce IL-23 in response to TLR2, TLR4, and TLR8 ligands, as well as the β-glucan receptor Dectin-1.

Human IL-23 induces proliferation of memory T cells and induces moderate levels of IFN-γ production by naïve and memory T cells, as compared to IL-12. In contrast, the mouse IL-23 biological activities are more distinctly different than those of mouse IL-12 suggesting the signaling or response elements (receptors) differ between species. The IL-23 receptor is also heterodimeric and shares the IL-12Rβ1 chain with IL-12, while the IL-23R chain is unique to IL-23. Signaling occurs through the Jak/STAT pathway and results in RORγt expression, which drives the differentiation of CD4+ T-cells towards the Th17 phenotype.

The monoclonal antibody HNU2319 neutralizes the bioactivity of IL-23 without affecting IL-12.