IL-23 p19 Mouse anti-Human, Clone: HNU2319, Functional Grade, eBioscience™

Mouse Monoclonal Antibody, Functional Grade

Brand:  Affymetrix eBioscience 16-5236-85

Product Code. 15208647

Disclaimers:

For Research Use Only.

Description

The HNU2319 monoclonal antibody is specific to the p19 subunit of human IL-23, a heterodimeric cytokine made up of two covalently linked subunits, p40 and p19. It is closely related to IL-12, with which it shares the p40 subunit. Dendritic cells and macrophages produce IL-23 in response to TLR2, TLR4, and TLR8 ligands, as well as the β-glucan receptor Dectin-1.

Human IL-23 induces proliferation of memory T cells and induces moderate levels of IFN-γ production by naïve and memory T cells, as compared to IL-12. In contrast, the mouse IL-23 biological activities are more distinctly different than those of mouse IL-12 suggesting the signaling or response elements (receptors) differ between species. The IL-23 receptor is also heterodimeric and shares the IL-12Rβ1 chain with IL-12, while the IL-23R chain is unique to IL-23. Signaling occurs through the Jak/STAT pathway and results in RORγt expression, which drives the differentiation of CD4⁺ T-cells towards the Th17 phenotype.

The monoclonal antibody HNU2319 neutralizes the bioactivity of IL-23 without affecting IL-12.

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Specifications

• Antigen: IL-23 p19
• Clone: HNU2319
• Conjugate: Unlabeled
• Formulation: aqueous buffer, no sodium azide
• Host Species: Murine
• Quantity: 500μg
• Storage Requirements: Store at 2-8°C.
• Monoclonal or Polyclonal: Monoclonal

• Applications: Cytokine Neutralization
• Concentration: 1mg/mL
• Format: Purified
• Gene Alias: Interleukin 23 p19, IL23 p19, IL23p19, IL-23p19
• Isotype: IgG1
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Target Species: Human