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IL-23 Mouse anti-Mouse, Clone: 5B2, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 14-7233-85

UNSPSC : 12352200

Code : Z2

Additional Details : Weight : 0.01000kg

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Product Code. 15268047

  • £231.74 / 500µg


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For Research Use Only.


Description

Description

The 5B2 antibody reacts with the p19 subunit of mouse IL-23. The 5B2 antibody in combination with the C17.8 antibody yields an improved IL-23 sandwich ELISA with greater sensitivity than was achievable with previous assays. The 5B2 antibody is a non-neutralizing antibody.

IL-23 is a heterodimeric cytokine composed of the p40 subunit of IL-12 disulfide-linked with a protein p19. p19, like p35 of IL-12, is biologically inactive by itself. IL-23 interacts with IL-12Rbeta1 and an additional, novel beta2-like receptor subunit with STAT4 binding domain, termed IL-23R. IL-23 is secreted by activated mouse and human dendritic cells. Biological activities of mouse IL-23 are distinct from those of mouse IL-12. Mouse IL-23 was found not to induce significant amounts of IFN gamma. Mouse IL-23 does induce strong proliferation of memory T cells (but not naïve T cells), whereas IL-12 has no effect on memory cells. Additionally, mouse IL-23 (but not IL-12) can activate mouse memory T cells to produce the proinflammatory cytokine IL-17. Human IL-23 has biological properties which are less distinct from human IL-12; human IL-23 induces proliferation of memory T cells and induces moderate levels of IFN gamma production by naïve and memory T cells, as compared to IL-12.
Specifications

Specifications

IL-23
5B2
Unlabeled
Purified
Murine
500μg
Store at 2-8°C.
Monoclonal
ELISA
0.5mg/mL
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Interleukin-23, p40, p19
IgG2b
RUO
Primary
Murine