missing translation for 'onlineSavingsMsg'
Learn More

IL-23 Mouse anti-Human, eFluor 660, Clone: 23dcdp, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 50-7823-42

Code : NEW

Additional Details : Weight : 0.23750kg

 View more versions of this product

Product Code. 15570047

  • £213.39 / 100 tests


EU Stock 6
Add to basket

Disclaimers:

For Research Use Only.


Description

Description

This 23dcdp monoclonal antibody reacts with the p19 subunit of human IL-23. This heterodimeric cytokine is composed of two disulfide-linked subunits, p40 and p19. It is closely related to IL-12, with which it shares the p40 subunit. The IL-23 receptor is also heterodimeric and shares the IL-12Rβ1 chain with IL-12, while the IL-23R chain is unique to the IL-23 receptor complex. IL-23R signaling occurs through the Jak/STAT pathway and results in RORγt expression, which promotes maintenance and proliferation of T helper 17 (Th17) cells.

Dendritic cells and macrophages produce high levels of p40 and low levels of IL-23 in response to TLR2, TLR4, and TLR8 ligands and agonists of the β-glucan receptor, Dectin-1. This is due to the presence of monomer and dimer forms of p40, while only a small portion associates with p19 to form IL-23. Our studies suggest donor variability, expression kinetics and type of stimulant can result in variation in IL-23 expression levels. Recent publications suggest the p19 subunit may also exist in the absence of association with p40.
Specifications

Specifications

IL-23
23dcdp
eFluor™ 660
Conjugated
Murine
100 Tests
Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal
Flow Cytometry (Intracellular Staining)
5μL (0.03μg)/test
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Interleukin-23 p19
IgG2b
RUO
Primary
Human
Videos