IL-23 Mouse anti-Human, eFluor 660, Clone: 23dcdp, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 50-7823-42

Code: NEW

Additional Details:
Additional Details: Weight: 0.23750kg



Disclaimers: For Research Use Only.

Product Code. 15570047

Quantity Price
1 £ 213.39 / 100 tests
EU Stock 8
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Description and Specification

Specification

Antigen IL-23
Host Species Mouse
Concentration 5μL (0.03μg)/test
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Isotype IgG2b
Quantity 100 tests
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Clone 23dcdp
Conjugate eFluor 660
Gene Alias Interleukin-23 p19
Primary or Secondary Primary
Format Conjugated
Species Reactivity Human
Monoclonal or Polyclonal Monoclonal
Regulatory Status RUO
Applications Flow Cytometry (Intracellular Staining)

This 23dcdp monoclonal antibody reacts with the p19 subunit of human IL-23. This heterodimeric cytokine is composed of two disulfide-linked subunits, p40 and p19. It is closely related to IL-12, with which it shares the p40 subunit. The IL-23 receptor is also heterodimeric and shares the IL-12Rβ1 chain with IL-12, while the IL-23R chain is unique to the IL-23 receptor complex. IL-23R signaling occurs through the Jak/STAT pathway and results in RORγt expression, which promotes maintenance and proliferation of T helper 17 (Th17) cells.

Dendritic cells and macrophages produce high levels of p40 and low levels of IL-23 in response to TLR2, TLR4, and TLR8 ligands and agonists of the β-glucan receptor, Dectin-1. This is due to the presence of monomer and dimer forms of p40, while only a small portion associates with p19 to form IL-23. Our studies suggest donor variability, expression kinetics and type of stimulant can result in variation in IL-23 expression levels. Recent publications suggest the p19 subunit may also exist in the absence of association with p40.