IL-22 Rat anti-Mouse, PerCP-eFluor 710, Clone: 1H8PWSR, eBioscience™

Rat Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 46-7221-80

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.25000kg



Disclaimers: For Research Use Only.

Product Code. 15351390

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Description and Specification

Specification

Clone 1H8PWSR
Applications Flow Cytometry (Intracellular Staining)
Species Reactivity Mouse
Monoclonal or Polyclonal Monoclonal
Conjugate PerCP-eFluor 710
Concentration 0.2mg/mL
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Isotype IgG1
Format Conjugated
Gene Alias Interleukin-22
Quantity 25μg
Primary or Secondary Primary
Regulatory Status RUO
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Host Species Rat
Antigen IL-22

The 1H8PWSR monoclonal antibody reacts with mouse interleukin(IL)-22. IL-22 is a 20kDa member of the IL-10 cytokine family that is secreted primarily by Th17, NK cells, and some other T cells. In in vitro Th17 cultures, induction of IL-22 expression is greater in response to IL-23 than IL-6 or TGF-ß, suggesting that this cytokine may be secreted by more fully differentiated Th17 cells in vivo. A heterodimer consisting of IL-10R2 and IL-22R1 serves as the receptor for IL-22. Th17-secreted IL-22 binds to the IL-22 receptor complexon target cells to induce the expression of anti-microbial peptides ß-defensin-2 and ß-defensin-3. Recently, it was demonstrated that IL-22 is able to protect hosts against bacterial infections of the lungs and gut.