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IL-22 Rat anti-Human, Mouse, PerCP-eFluor 710, Clone: IL22JOP, eBioscience™

Rat Monoclonal Antibody

Brand:  Affymetrix eBioscience 46-7222-82

Code : NEW

Additional Details : Weight : 0.09500kg

 View more versions of this product

Product Code. 15579356

  • £237.72 / 100µg


Estimated Shipment date
from Supplier 25-09-2017
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Disclaimers:

For Research Use Only.


Description

Description

The monoclonal antibody IL22JOP reacts with and inhibits the bioactivity of human and mouse IL-22. IL-22 is a 20kDa member of the IL-10 cytokine family that is secreted primarily by Th17 cells, NK cells, and other T cells. Compared to IL-6 or TGF beta, IL-23 can induce greater levels of IL-22 in in vitro-differentiated Th17 cells. This observation suggests that IL-22 may be secreted by more fully differentiated Th17 cells in vivo. Recently, it was demonstrated that IL-22 could protect hosts from bacterial infection of the lungs and gut. Moreover, it has been reported that anti-CD3/CD28-induced production of IL-22 by PBMCs was elevated significantly in asthma patients compared to control patients. Flow cytometric analysis also showed that the frequencies of IL-17+IL-22+ CD4 T cells were increased in PBMCs from patients with ankylosing spondylitis and rheumatoid arthritis.
Specifications

Specifications

IL-22
IL22JOP
PerCP-eFluor 710
Conjugated
Rat
100μg
Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal
Flow Cytometry (Intracellular Staining)
0.2mg/mL
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Interleukin-22, IL22
IgG2a
RUO
Primary
Murine