IL-22 Rat anti-Human, Mouse, Clone: IL22JOP, Functional Grade, eBioscience™
Rat Monoclonal Antibody, Functional Grade
Brand: Affymetrix eBioscience 16-7222-85
Code : Z2
Additional Details : Weight : 0.01000kg
DescriptionThe monoclonal antibody IL22JOP reacts with and inhibits the bioactivity of human and mouse IL-22. IL-22 is a 20kDa member of the IL-10 cytokine family that is secreted primarily by Th17 cells, NK cells, and other T cells. Compared to IL-6 or TGF beta, IL-23 can induce greater levels of IL-22 in in vitro-differentiated Th17 cells. This observation suggests that IL-22 may be secreted by more fully differentiated Th17 cells in vivo. Recently, it was demonstrated that IL-22 could protect hosts from bacterial infection of the lungs and gut. Moreover, it has been reported that anti-CD3/CD28-induced production of IL-22 by PBMCs was elevated significantly in asthma patients compared to control patients. Flow cytometric analysis also showed that the frequencies of IL-17+IL-22+ CD4 T cells were increased in PBMCs from patients with ankylosing spondylitis and rheumatoid arthritis.
|Store at 2-8°C.|
|aqueous buffer, no sodium azide|