IL-22 Rat anti-Human, Mouse, Clone: IL22JOP, Functional Grade, eBioscience™

Rat Monoclonal Antibody, Functional Grade

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 16-7222-82

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.01000kg



Disclaimers: For Research Use Only.

Product Code. 15228787

Quantity Price
1 £ 66.65 / 100µg
EU Stock 1
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Description and Specification

Specification

Storage Requirements Store at 2-8°C.
Formulation aqueous buffer, no sodium azide
Antigen IL-22
Concentration 1mg/mL
Conjugate Unlabeled
Gene Alias Interleukin-22, IL22
Isotype IgG2a
Species Reactivity Human, Mouse
Monoclonal or Polyclonal Monoclonal
Applications Cytokine Neutralization
Clone IL22JOP
Quantity 100μg
Regulatory Status RUO
Host Species Rat
Format Purified
Primary or Secondary Primary

The monoclonal antibody IL22JOP reacts with and inhibits the bioactivity of human and mouse IL-22. IL-22 is a 20kDa member of the IL-10 cytokine family that is secreted primarily by Th17 cells, NK cells, and other T cells. Compared to IL-6 or TGF beta, IL-23 can induce greater levels of IL-22 in in vitro-differentiated Th17 cells. This observation suggests that IL-22 may be secreted by more fully differentiated Th17 cells in vivo. Recently, it was demonstrated that IL-22 could protect hosts from bacterial infection of the lungs and gut. Moreover, it has been reported that anti-CD3/CD28-induced production of IL-22 by PBMCs was elevated significantly in asthma patients compared to control patients. Flow cytometric analysis also showed that the frequencies of IL-17+IL-22+ CD4 T cells were increased in PBMCs from patients with ankylosing spondylitis and rheumatoid arthritis.