missing translation for 'onlineSavingsMsg'
Learn More

IL-17FF (homodimer) Mouse anti-Human, eFluor 660, Clone: WU24A4P, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 50-9178-42

Code : NEW

Additional Details : Weight : 0.23750kg

 View more versions of this product

Product Code. 15580087

  • £182.82 / 100 tests


Estimated Shipment date
from Supplier 03-07-2017
Add to basket

Disclaimers:

For Research Use Only.


Specifications

Description

The WU24A4P monoclonal antibody reacts with human interleukin (IL)-17F homodimer (IL-17FF). This antibody specifically reacts with this homodimer and has no reactivity for the IL-17AF heterodimer. IL-17FF is a 34kDa member of the IL-17 family, which includes IL-17A, B, C, D, and E (IL-25). Within this family, IL-17A and IL-17F are produced preferentially by T helper 17 (Th17) cells, with other members produced more widely. IL-17F and IL-17A have many overlapping functions, but knockout studies have shown each to have independent functions as well. In vitro cultured Th17 cells have been shown to express IL-17FF and IL-17AA homodimers and IL-17AF heterodimers depending on the culture conditions and their differentiation state. Together, these three dimers signal through the IL-17RA/IL-17RC receptor complex to mediate immune responses at mucosal interfaces and are found at lesion sites in inflammatory bowel disease, asthma, atopic dermatitis and rheumatoid arthritis.

While other clones with specificity for IL-17F, such as SHLR17, react with the IL-17F monomer in the context both IL-17FF and IL-17AF dimers, clone WU24A4P reacts specifically with IL-17FF homodimer and does not detect IL-17AF heterodimer.
Description & Specifications

Specifications

IL-17FF (homodimer)
WU24A4P
eFluor 660
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Murine
100 Tests
Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal
Flow Cytometry (Intracellular Staining)
5μL (0.25μg)/test
Conjugated
Interleukin-17F
IgG2b
RUO
Primary
Human