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IL-17F Monoclonal Antibody (eBio18F10), Alexa Fluor™ 488, eBioscience™, Invitrogen™
Rat Monoclonal Antibody
£134.00 - £263.00
Specifications
Antigen | IL-17F |
---|---|
Clone | eBio18F10 |
Concentration | 0.5 mg/mL |
Applications | Flow Cytometry |
Classification | Monoclonal |
Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
---|---|---|---|---|---|---|---|---|---|
Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
15322080
|
Affymetrix eBioscience
53-7471-80 |
25 μg |
£134.00
25µg |
Estimated Shipment: 10-04-2024 Log in to see stock. |
Please sign in to purchase this item. Need a web account? Register with us today! | ||||
15332080
|
Affymetrix eBioscience
53-7471-82 |
100 μg |
£263.00
100µg |
Estimated Shipment: 08-05-2024 Log in to see stock. |
Please sign in to purchase this item. Need a web account? Register with us today! | ||||
Description
Description: The eBio18F10 antibody reacts with mouse IL-17F. IL-17F is a 37 kD homodimer of the IL-17 family and a signature Th17 marker. Of all the six IL-17 family members, IL-17F and IL-17A share the strongest homology (50% amino acid identity), and the two genes are located in the same chromosomal region. Recent studies have demonstrated coordinated regulation of IL-17A and IL-17F during Th17 differentiation. Expression of IL-17F and IL-17A has been detected in activated human peripheral blood lymphocytes, specifically by activated human CD4+ T cells. In addition to IL-17A, differentiated Th17 cells also produce IL-17F and IL-22 upon re-activation. Like IL-17A, IL-17F has been linked with inflammatory diseases. IL-17F and IL-17A expression has been observed in tissue samples from various autoimmune diseases, such as rheumatoid arthritis, multiple sclerosis, psoriasis, inflammatory bowel disease, and asthma. IL-17F treatment of airway epithelium, vein endothelial cells, and fibroblasts has been reported to induce expression of IL-6, IL-8, GRO-alpha, ENA-78, TGF-beta, MCP-1, G-CSF, GM-CSF, and ICAM-1. Like IL-17A, IL-17F is a disulfide-linked homodimeric glycoprotein. The IL-17F homodimer includes a classical cysteine knot motif, which is found also in the TGF-beta, BMP, and NGF superfamilies. The presence of the cysteine knot motif suggested the possibility of a heterodimeric structure, as was reported for TGF-beta and inhibin/activin.
IL-17F Monoclonal antibody specifically detects IL-17F in Mouse samples. It is validated for Flow Cytometry.Specifications
IL-17F | |
0.5 mg/mL | |
Monoclonal | |
Liquid | |
RUO | |
PBS with 0.09% sodium azide; pH 7.2 | |
C87042; CANDF6; cytokine ML-1; IL17F; IL-17F; IL-24; ILN; Interleukin; interleukin 17F; Interleukin17F; interleukin-17F; interleukin-24; ML1; ML-1; mutant IL-17F | |
IL17F | |
Primary | |
4° C, store in dark, DO NOT FREEZE! | |
IL17F |
eBio18F10 | |
Flow Cytometry | |
Alexa Fluor 488 | |
Rat | |
Mouse | |
Q7TNI7 | |
257630 | |
IgG2a κ | |
Affinity chromatography | |
Antibody |
For Research Use Only.