IL-17F Rat anti-Human, PE, Clone: SHLR17, eBioscience™

Rat Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 12-7169-41

Code: NEW

Additional Details:
Additional Details: Weight: 0.23750kg



Disclaimers: For Research Use Only.

Product Code. 15517106

Quantity Price
1 £ 78.88 / 25 tests
EU Stock 1
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Description and Specification

Specification

Applications Flow Cytometry (Intracellular Staining)
Monoclonal or Polyclonal Monoclonal
Quantity 25 tests
Isotype IgG1
Host Species Rat
Clone SHLR17
Format Conjugated
Species Reactivity Human
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Primary or Secondary Primary
Conjugate PE
Regulatory Status RUO
Antigen IL-17F
Gene Alias Interleukin-17F
Concentration 5μL (0.5μg)/test

The SHLR17 monoclonal antibody reacts with human interleukin (IL)-17F. IL-17F is a homodimeric, 34kDa member of the IL-17 family, which includes IL-17(A), B, C, D, E (IL-25). Within this family, IL-17A and IL-17F are produced preferentially by T helper 17 (Th17) cells, with other members produced more widely. IL-17F and IL-17A have many overlapping functions, but knockout studies have shown each to have independent functions as well. In vitro cultured Th17 cells have been shown to express IL-17F and IL-17A homodimers and IL-17A/F heterodimers depending on the culture conditions and their differentiation state. A heterodimer of IL-17RA and IL-17RC has been shown to bind IL-17F, resulting in target cell-secretion of pro-inflammatory cytokines and chemokines, as well as neutrophil recruitment.