IL-17F Rat anti-Human, Clone: SHLR17, Functional Grade, eBioscience™

Rat Monoclonal Antibody, Functional Grade

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 16-7169-85

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.01000kg



Disclaimers: For Research Use Only.

Product Code. 15238777

Quantity Price
1 £ 213.39 / 500µg
Estimated Shipment date
from Supplier 30-03-2017
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Description and Specification

Specification

Isotype IgG1
Conjugate Unlabeled
Formulation aqueous buffer, no sodium azide
Storage Requirements Store at 2-8°C.
Concentration 1mg/mL
Clone SHLR17
Regulatory Status RUO
Antigen IL-17F
Primary or Secondary Primary
Gene Alias Interleukin-17F
Format Purified
Quantity 500μg
Species Reactivity Human
Host Species Rat
Applications Functional Assay
Monoclonal or Polyclonal Monoclonal

This SHLR17 monoclonal antibody reacts with human interleukin (IL)-17F. IL-17F is a homodimeric, 34kDa member of the IL-17 family, which includes IL-17(A), B, C, D, E (IL-25). Within this family, IL-17A and IL-17F are produced preferentially by T helper 17 (Th17) cells, with other members produced more widely. IL-17F and IL-17A have many overlapping functions, but knockout studies have shown each to have independent functions as well. In vitro cultured Th17 cells have been shown to express IL-17F and IL-17A homodimers and IL-17A/F heterodimers depending on the culture conditions and their differentiation state. A heterodimer of IL-17RA and IL-17RC has been shown to bind IL-17F, resulting in target cell-secretion of pro-inflammatory cytokines and chemokines, as well as neutrophil recruitment.

This SHLR17 monoclonal antibody neutralizes the bioactivity of IL-17F homodimers without affecting IL-17A/F heterodimers.