IL-17F Rat anti-Human, Clone: SHLR17, Functional Grade, eBioscience™

Rat Monoclonal Antibody, Functional Grade

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 16-7169-82

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.01000kg



Disclaimers: For Research Use Only.

Product Code. 15228777

Quantity Price
1 £ 91.11 / 100µg
Estimated Shipment date
from Supplier 04-05-2017
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Description and Specification

Specification

Storage Requirements Store at 2-8°C.
Gene Alias Interleukin-17F
Concentration 1mg/mL
Antigen IL-17F
Isotype IgG1
Primary or Secondary Primary
Formulation aqueous buffer, no sodium azide
Regulatory Status RUO
Species Reactivity Human
Monoclonal or Polyclonal Monoclonal
Clone SHLR17
Applications Functional Assay
Conjugate Unlabeled
Format Purified
Quantity 100μg
Host Species Rat

This SHLR17 monoclonal antibody reacts with human interleukin (IL)-17F. IL-17F is a homodimeric, 34kDa member of the IL-17 family, which includes IL-17(A), B, C, D, E (IL-25). Within this family, IL-17A and IL-17F are produced preferentially by T helper 17 (Th17) cells, with other members produced more widely. IL-17F and IL-17A have many overlapping functions, but knockout studies have shown each to have independent functions as well. In vitro cultured Th17 cells have been shown to express IL-17F and IL-17A homodimers and IL-17A/F heterodimers depending on the culture conditions and their differentiation state. A heterodimer of IL-17RA and IL-17RC has been shown to bind IL-17F, resulting in target cell-secretion of pro-inflammatory cytokines and chemokines, as well as neutrophil recruitment.

This SHLR17 monoclonal antibody neutralizes the bioactivity of IL-17F homodimers without affecting IL-17A/F heterodimers.